磁性介孔纳米硅微球的制备及药物释放行为研究  

Preparation of Magnetic Hollow Mesoporous Silica Spheres and Their Drug Delivery Property

作　　者：孔墨奇 徐慧[1] 何勇菊 张鹏华[1] 

机构地区：[1]中南大学物理与电子学院,长沙410083

出　　处：《材料导报》2014年第10期12-15,共4页Materials Reports

基　　金：中南大学研究生创新课题

摘　　要：以十八烷基三甲氧基硅烷为模板剂,在室温下制备了核壳结构Fe3O4介孔纳米硅球。颗粒拥有良好的均一性,粒径约为100nm。采用液氮吸脱附分析得到其BET比表面积为1001m2/g,BJH孔容为0.994cm3/g。每个纳米微球中有且仅有一个直径约为20nm的Fe3O4铁磁核。采用PPMS-9分析仪测得其拥有顺磁性且磁饱和值约为14.5emu/g。这种磁性介孔纳米颗粒对阿司匹林的载药量能够达到34%(质量分数),在药物缓释方面拥有良好的前景。Core-shell Fe3O4@SiO2 hollow mesoporous spheres with large cavities were successfully prepared by using the n-octadecyltrimethoxysilane （C18TMS） as the templates at room temperature.The nanospheres are well monodisperse and nearly uniform.The N2 sorption analysis indicated that the Brunauer-Emmett-Teller （BET） surface area reaches 1001 m2/g and the Barrett-Joyner-Halanda （BJH） pore volume reaches 0.994 cm3/g,and only one Fe3O4 particle of ca.20 nm in diameter is encapsulated in each sphere.The magnetic measurement indicated that the Fe3O4@SiO2 hollow mesoporous spheres exhibited ferromagnetic behavior with the magnetization saturation of 14.5 emu/g.When Aspirin was loaded,the material showed high drug loading capacity of 34 wt％.Therefore,this kind of magnetic hollow mesoporous spheres provides to be a very promising nanocarrier in a targeted drug delivery system.

关 键 词：介孔 硅 磁性 药物缓释 

分 类 号：O613.72[理学—无机化学]