扩张型心肌病患者肠道病毒感染及其对预后的影响  

Enterovirus infection in patients with dilated cardiomyopathy and its effect on prognosis

作　　者：陈安勇[1,2] 李健[1] 陈猛[2] 

机构地区：[1]青岛大学附属医院,山东青岛266003 [2]济宁医学院附属医院

出　　处：《山东医药》2014年第14期35-36,共2页Shandong Medical Journal

基　　金：山东省自然科学基金面上项目(ZR2010HM081);中国博士后科学基金资助项目(2012M511462)

摘　　要：目的探讨肠道病毒感染在扩张型心肌病(DCM)发生发展中的作用。方法采用RT-PCR法检测109例DCM患者肠道病毒RNA表达,其中肠道柯萨奇B组病毒RNA阳性49例(阳性组),阴性60例(阴性组)。采用ELISA法测定两组血清病毒RNA表达水平,比较两组近期预后(心衰再发率、再入院率、病死率等)。结果阳性组血清肠道病毒RNA水平明显高于阴性组,P<0.05;再入院率、急性心衰再发率、病死率均明显高于阴性组(P均<0.05)。结论肠道病毒感染在扩张型心肌病发生发展过程中起重要作用;肠道病毒RNA高表达者近期预后较差。Objective To investigate the function of enterovirus infection in the occurrence and development of dilated cardiomyopathy （DCM）.Methods Reverse transcriptase-polymerase chain reaction （RT-PCR） method was used to de-tect the enterovirus RNA expression of 109 cases of DCM patients , in which 49 patients were Coxsackie B virus RNA-posi-tive （ positive group ） and negative ones were found in 60 cases （ negative group ） .The serum coxsackievirus and adenovirus RNA contents in the two groups were detected by ELISA , and the short-term prognosis （ including mortality and readmission records and other adverse cardiac events ） was compared .Results The serum enterovirus RNA in the positive group was significantly higher than that of the negative group （P＆lt;0.05）, and the readmission rate, acute heart failure recurrence rate, mortality rate were significantly higher than those of the negative group （P＆lt;0.05）.Conclusion Enterovirus infec-tion plays an important role in the occurrence and development of DCM , and the short-term prognosis of patients with higher enterovirus RNA is worse .

关 键 词：扩张型心肌病 肠道病毒 感染 

分 类 号：R542.2[医药卫生—心血管疾病]