前列腺干细胞研究进展  

Prostate stem cells: An update

作　　者：韩广玮[1] 易善红[1] 

机构地区：[1]第三军医大学附属新桥医院泌尿外科,重庆400037

出　　处：《中华男科学杂志》2014年第5期460-463,共4页National Journal of Andrology

摘　　要：干细胞具有强大的自我更新、多向分化潜能和高度增殖的特性,其在多种疾病的发生和疾病治疗中的作用已越来越受到人们重视。前列腺干细胞包括上皮干细胞和间充质干细胞,其中上皮干细胞表面标记物包括细胞角蛋白、干细胞抗原-1、整合素α2β1、CD49f、CD133、CD117、CD44等,间充质干细胞的标记物包括CD30、CD44、CD133、神经元特异性烯醇化酶和血管内皮生长因子受体-1。前列腺疾病的发生与干细胞的参与密切相关。本文就前列腺干细胞近年来的相关研究进展作一综述。Stem cells are characterized by self-renewing, muhipotent differentiation, and high proliferation and receiving more and more attention for their roles in the development and management of various diseases. There are epithelial stem cells and mesenchyreal stem ceils in the prostate. The markers of the epithelial stem cells include cytokeratin, stem cell antigen-1, and integrinsα2β1, CD49f, CD133, CD117, and CD44. The markers of the mesenchymal stem cells include CD30, CD44, CD133, neuron-specific enolase, and vascular endothelial growth factor receptor-1. Prostate stem cells are involved in the development and treatment of prostatic diseases. This review focuses on the latest progress in the studies of prostate stem ceils. Nat1 J Androi, 2014, 20 （5） ： 460 -463

关 键 词：干细胞 表面标记物 前列腺疾病 

分 类 号：R697.3[医药卫生—泌尿科学]