紧急避孕药与异位妊娠关系的Meta分析  

Emergency Contraceptive and Risk of Ectopic Pregnancy: A Meta Analysis

作　　者：谢海霞[1] 常淑芳[1] 孙江川[1] 

机构地区：[1]重庆医科大学附属第二医院,重庆400010

出　　处：《实用妇产科杂志》2014年第5期373-376,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的：系统评价紧急避孕药与异位妊娠发生的关系，为更好地预防异位妊娠提供依据。方法：采用Cochrane系统评价方法，计算机检索Embase、Pubmed、中国知网、维普、万方数据库，检索时限从1990～2012年，纳入紧急避孕药与异位妊娠发生的病例一对照研究。由评价者选择文献、提取资料、评价质量并交叉核对后，用Review5.0软件进行统计分析，计算纳入病例一对照研究的合并优势比（OR）及其95％CI。结果：纳入11个痛例一对照研究（病例组2059例，对照组3996例），其质量评价均6分以上。Meta分析结果显示，紧急避孕药与异位妊娠之间存在明显的关联性，合并计算的OR 3.27，95％CI（2.64～4.06）。结论：紧急避孕药增加异位妊娠的风险，但由于纳入的文献研究数量较少，上述结论尚需开展更多高质量研究。Objective： To review and evaluate theliteratures about the association between emergency contraceptive and the risk of ectopic pregnancy, providing the evidence for prevention of ectopic pregnancy. Methods：Relevant retrospective nested case-control studies from 1990 -2012 were identified by systemati- cally searching Embase, Pubmed, CNKI, Weipu, Wangfang. The following original data were extracted in a standardized manner from eligible studies： author, study design. The incorporated OR（odds ratio） and 95% CI of case-control studies were calculated, respectively. Results：l 1 case-control studies with 6 score or more in quality evaluation were included. Result of meta-analysis of these studies showed a significant association be-tween emergency contraceptive and ectopic Pregnancy,with an OR value of 3.27 and 95% CI of 2.64 -4. 06. Conclusions：Oral emergency contraceptive increases the risk of ectopic pregnancy, However, more high-quality researches are needed to confirm the findings.

关 键 词：紧急避孕 异位妊娠 左炔诺孕酮 米非司酮 META分析 危险因素 

分 类 号：R714.22[医药卫生—妇产科学]