^(99m)Tc-HYNIC-TOC SPECT/CT显像探测神经内分泌肿瘤肝转移灶的临床价值  

Evaluation of ^(99m)Tc-hydrazinonicotinamide-Tyr^3-octreotide SPECT/CT in detection of liver metastases in patients with neuroendocrine tumors

作　　者：蒋津津[1,2] 徐俊彦[1,2] 许晓平[1,2] 杨忠毅[1,2] 张建岗[1,2] 陆晓聆 章英剑[1,2] 

机构地区：[1]复旦大学附属肿瘤医院核医学科,复旦大学上海医学院肿瘤学系,上海200032 [2]复旦大学生物医学影像研究中心,上海200032

出　　处：《肿瘤影像学》2014年第1期14-18,共5页Oncoradiology

摘　　要：目的探讨99mTc-HYNIC-TOC显像探测神经内分泌肿瘤肝(NET)转移灶的价值。方法对17例行99mTc-HYNIC-TOC检查的NET肝转移患者进行回顾性分析,其原发灶为直肠NET者13例、胰腺NET者3例、腹腔来源NET者1例。静脉注射10~15 mCi 99mTc-HYNIC-TOC后2 h行全身和腹部SPECT/CT断层显像,对各肝脏转移灶进行图像分析,测量靶/非靶放射性计数比值(T/NT)。结果 99mTc-HYNIC-TOC对NET患者肝转移的诊断阳性率为76.5%(13/17),阳性病灶T/NT比值平均为3.73±2.57(1.50~13.03,n=46),病灶检出率为92.0%(46/50),同机低剂量CT和同期增强诊断CT病灶检出率分别为40.0%(20/50)和64.7%(11/17)。99mTc-HYNIC-TOC SPECT/CT检出最小病灶最大径仅7 mm,T/NT值达2.68。此外,全身平面显像配合SPECT/CT断层显像可更准确发现更多肝内转移灶,对肝转移灶疗效评价也有较好的应用价值。结论 99mTc-HYNIC-TOC SPECT/CT显像可准确、灵敏地探测肝转移灶。Objective To evaluate the value of 99mTc-hydrazinonicotinamide-Tyr3-octreotide （99mTc-HYNIC-TOC） in detection of liver metastases in patients with neuroendocrine tumors. Methods 99mTc-HYNIC-TOC imaging data of 17 neuroendocrine tumor patients with liver metastases were analyzed retrospectively, including 13 rectal, 3 pancreatic and 1 abdominal neuroendocrine tumors. Total body imaging and SPECT/CT imaging were obtained 2 h after intravenous injection of 10-15 mCi 99mTc-HYNIC-TOC. Results 76.5% （13/17） of neuroendocrine tumor patients with liver metastases were positive on 99mTc-HYNIC-TOC imaging. The average target/non-target （T/NT） value of positive lesions was 3.73±2.57＆amp;nbsp;（1.50-13.03, n=46）. The detection rate for all the lesions was 92.0% （46/50）. The detection rates of TOC imaging with low-dose CT and normal-dose CT were 40.0%（20/50） and 64.7%（11/17） respectively. The size of the smallest lesion detected was only 7 mm, with T/NT value of 2.68. Besides, SPECT/CT scan could provide more correct information than planar imaging. Conclusion 99mTc-HYNIC-TOC SPECT/CT is an excellent method for detection of liver metastases in the patients with neuroendocrine tumors.

关 键 词：99mTc-HYNIC-TOC显像 神经内分泌肿瘤 肝转移 

分 类 号：R445.5[医药卫生—影像医学与核医学]