七氟醚全身麻醉后小儿应用右旋美托嘧啶对呼吸功能的影响研究  

STUDY OF APPLICATION OF DEXMEDETOMIDINE EFFECT ON RESPIRATORY FUNCTION AFTER SEVOFLURANE ANESTHESIA

作　　者：刘琪琳[1] 

机构地区：[1]川北医学院附属医院,四川南充637000

出　　处：《牡丹江医学院学报》2014年第2期22-23,共2页Journal of Mudanjiang Medical University

基　　金：川北医学院附属医院科研课题(2013-23)

摘　　要：目的：探究七氟醚全身麻醉后小儿应用右旋美托嘧啶对呼吸功能的影响。方法：选取2011—02—2013—03间我院进行七氟醚全身麻醉的患儿50例，按数字法随机的分为观察组与对照组各25例，观察组患儿给予0．5ug／kg右旋美托嘧啶，对照组患儿给予同剂量的生理盐水，观察两组患者的在不同时间点PETCO2（mmHg）的变化，及呼吸恢复时间与拔管时间。结果：经右旋关托嘧啶干预后，观察组患者在8rain、12min后各时间点的PETCO2数值均优于对照组，差异有统计学意义（P〈0．05）；经干预后，观察组呼吸恢复时间、拔管时间明显优于对照组，差异有统计学意义（P〈0．05）。结论：右旋美托嘧啶能有效的减轻七氟醚全身麻醉对小儿呼吸功能的影响，临床效果明确，值得在临床上推广与应用。Objective：To explore the effects of application of dexmedetomidine on respiratory function after sevoflurane anesthesia. Methods：From 2011 February - 2013 year in March sevoflurane anesthesia was used in children 50 cases, randomly divided into observation group and control group,25 cases in each group, the observation group were given 0. 5ug/kg dexmedetomidine, saline control group given the same dose. Two groups were observed at different points and PETCO2 （mmHg） changes, and breathing recovery time and extubation time. Results： After dexmedetomidine intervention, observation of patients in group 8min, PETCO2 value of each time point after 12min are better than the control group, the difference was statistically significant （ P 〈 0. 05 ） ; after intervention, the observation group breathing recovery time, extubation time was significantly better than the control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion ： Dexmedetomidine can effectively reduce the effect of sevoflurane anesthesia on respiratory function in children, has definite clinical effect, worthy of clinical popularization and application.

关 键 词：七氟醚 全身麻醉 右旋美托嘧啶 呼吸功能 

分 类 号：R56[医药卫生—呼吸系统]