噪声对机体血清SOD和MDA表达水平的影响  

The Effects of Noise on the Expression Levels of Serum SOD and MDA in Human Body

作　　者：何庆文 易桂林 肖才文[1] 张红波[1] 严雁琳 李济超 徐翔[1] 李汉琳[1] 周卫[1] 万吴汉徽[1] 

机构地区：[1]江汉大学附属医院耳鼻喉科,武汉430015 [2]武汉市职业病防治院临床检验科,武汉430015

出　　处：《医学综述》2014年第9期1658-1659,共2页Medical Recapitulate

基　　金：武汉市卫生局科研项目(WX12C56)

摘　　要：目的探讨噪声对机体血清超氧化物歧化酶(SOD)和丙二醛(MDA)表达水平的影响。方法检测噪声暴露厂企业工人(噪声暴露组,n=80)和其他非噪声暴露企业工人(对照组,n=80)血清SOD和MDA表达水平,同时对两组工人进行纯音听阈测试。结果噪声暴露组工人接噪强度显著高于对照组[(87.5±2.7)dB vs(82.2±2.4)dB](P<0.05);噪声暴露组血清SOD表达水平显著低于对照组(P<0.05),血清MDA表达水平明显高于对照组(P<0.05);两组语频听力与高频听力损失比较差异有统计学意义(P<0.05);血清中MDA与SOD表达水平呈负相关(P<0.05),与双耳高频听力损失呈正相关(P<0.05)。结论血清SOD表达水平对噪声所致机体氧化损伤有一定的保护作用。Objective To investigate the effects of noise on the expression levels of serum superoxide dismutase（ SOD ） and malondialdehyde （MDA） in human body. Methods The serum SOD and MDA expression levels in workers at noisy factory （noise exposure group, n = 80） and the others at non-noisy facto- ry（ control group ,n = 80 ） were investigated while sound hearing threshold test were performed for the two groups. Results The noise exposure intensity of the noise exposure group （87.5 ± 2.7 ） dB was significantly higher than that of the control group （ 82.2 ± 2.4） dB ; the serum SOD expression levels of the noise exposure group were significantly lower than those of the control group（ P 〈 0.05 ）, while the serum MDA levels of the noise exposure group were significantly higher than those of the control group （ P 〈 0.05 ） ; there was a significant difference between the two groups in speech frequency and high-frequency hearing loss（ P 〈 0.05 ） ; the serum levels of MDA was negatively correlated to SOD expression （P 〈 0.05 ）, but positively to binaural high-frequency hearing loss （ P 〈 0.05 ）. Conclusion Serum SOD expression level has a protective effect on oxidative damage caused by noise.

关 键 词：噪声 超氧化物歧化酶 丙二醛 

分 类 号：R764[医药卫生—耳鼻咽喉科]