血清胱抑素C和尿Ⅳ型胶原水平在儿童过敏性紫癜肾损伤中的变化及其意义  

Changes and Significance of Serum Cystatin C and Urinary Type Ⅳ Collagen Levels in Children with Henoch-Schonlein Purpura with Renal Injury

作　　者：刘伟华[1,2] 肖延风[1] 尹春燕[1] 

机构地区：[1]西安交通大学医学院第二附属医院儿科,西安710004 [2]西安市第一医院儿科,西安710002

出　　处：《医学综述》2014年第9期1660-1661,1665,共3页Medical Recapitulate

摘　　要：目的研究血清胱抑素C(CysC)、尿Ⅳ胶原(Ⅳ-C)水平在小儿过敏性紫癜(HSP)肾损伤中的变化及临床意义。方法将2009年11至2010年8月西安交通大学医学院第二附属医院儿科收治的60例HSP患儿按照尿常规和生化检查结果异常程度分为肾损A组、肾损B组、非肾损组;另外选取同期的同龄健康者28例作为对照组。采用酶联免疫双抗体夹心法检测CysC和Ⅳ-C水平。结果肾损A组和肾损B组Ⅳ-C水平显著高于对照组(P<0.01),肾损A组、肾损B组及非肾损组的CysC水平均高于正常对照组(P<0.01)。HSP患儿Ⅳ-C与CysC水平呈正相关(r=0.86,P<0.05)。结论Ⅳ-C、CysC可反映HSP患儿的肾小球损害程度,联合检测可以作为小儿HSP肾小球损伤早期、灵敏的诊断指标。Objective To study the changes and clinical significance of cystatin C （CysC）, urinary collagen fibrin Ⅳ （ IV-C ） levels in children with Henoch-Schonlein purpura（HSP） with renal injury. Methods A total of 60 children with HSP admitted to the Second Affiliated Hospital of Medical School of Xi＇an Jiaotong University from Nov. 2009 to Aug. 2010 were divided into three groups based on abnormal degrees of urine routine and biochemical examination results, which were kidney injury group A （KI-Group A） , kidney injury group B （KI-Group B） , and non-kidney injury group （non-KI-Group）. And 28 healthy children with the same age during the same period were selected as the control group. A sandwich enzyme-linked immu- nosorbent assay（ELISA） was employed to determine the values of CysC, Ⅳ-C. Results Ⅳ-C levels of KI-Group A and KI-Group B were significantly higher than the control group （ P 〈 0.01 ）. CysC levels of KI-Group A, KI-Group B, and non-KI Group were higher than the control group （P 〈 0.01 ）. It was shown that the level of Ⅳ-C was negatively correlated with CysC （ r = 0.86, P 〈 0.05 ）. Conclusion Ⅳ-C and CysC can reflect the glomerular injury degree in children with HSP,the combined examination of which can a sensitive diagamstic index for early HSP domerular iniury.

关 键 词：过敏性紫癜 早期肾损害 血清胱抑素C 尿Ⅳ型胶原 

分 类 号：R725.5[医药卫生—儿科]