肾功能异常对阻塞性睡眠呼吸暂停低通气综合征疾病发生的影响  

Impact of Renal Dysfunction on the Incidence of Obstructive Apnea and Hypopnea Syndrome: a Retrospective Analysis

作　　者：罗洋[1] 龚勇[1] 甘红兵[1] 耿培宏[1] 

机构地区：[1]首都医科大学附属北京天坛医院肾内科,北京100050

出　　处：《中国中西医结合肾病杂志》2014年第4期318-320,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：首都卫生发展科研专项项目(No.首发2011-2004-03)

摘　　要：目的：评价肾功能异常对阻塞性睡眠呼吸暂停低通气综合征（ OSAHS）疾病进展的作用。方法：对2011年8月-2013年8月在首都医科大学附属北京天坛医院睡眠检测中心行睡眠呼吸监测的成人患者临床资料进行回顾性分析。结果：116例患者中。 OSAHS及非OSAHS分别为74例及42例。两组年龄、性别、糖尿病、高脂血症、高血压病及肾小球滤过率（eGFR）差异均存在统计学意义（P〈0.05）。多因素 Logistic回归提示年龄（OR：2.6,95%CI：1.2-7.5）、肾功能异常（eGFR〈60 ml·min-1·1.73 m-2）（OR：1.3,95%CI：1.1-10.2）、糖尿病（OR：3.5,95%CI：2.1-18.3）、肥胖（BMI〉28）（OR：6.9,95%CI：3.1-28.1）及高三酰甘油血症（OR：1.7,95%CI：1.4-22.5）为 OSAHS 发生独立相关风险因素（P 〈0.05）。结论：肾功能异常是促进OSAHS发生的独立风险因素。Objective：To analysis the impact of renal dysfunction on the progression of obstructive apnea and hypopnea syn-drome （ OSAHS） . Methods：A retrospective study was performed among Chinese adult patients who were admitted polysomnography examination overnight. Patients were divided into OSAHS group （AHI≥5） and non-OSAHS group （AHI〈5）;multivariate Logistic regression analysis were performed to determine the risk factors of the incidence of OSAHS. Results：Overall （ total 116 patients inclu-ding 85 male and 31 female,median age was 60. 2 ＆#177; 19. 6 years old）,74 patients were OSAHS and 42 were in non-OSAHA group. There were significant different in age,gender,hypertriglyceridemia ,lower estimated glomerular filtration rate （ eGFR〈60 ml·min-1 ·1. 73 m-2）,hypertension,diabetes and obesity among those different groups（P〈0. 05）. Logistic regression showed that age （OR：2.6,95%CI：1.2-7.5）,renal dysfunction marked as lower eGFR （OR：1. 3,95%CI：1. 1 -10. 2）,diabetes （OR：3. 5,95%CI：2. 1-18. 3）,obesity marked as BMI〉28（OR：6. 9,95%CI：3. 1-28. 1）,hypertriglyceridemia （OR：1. 7,95%CI：1. 4-22. 5） were significantly associated with the occurrence of OSAHS （P〈0. 05）. Conclusion：Renal dysfunction,together with age,diabetes,obesi-ty,hypertriglyceridemia are independent risk factors of the incidence of OSAHS.

关 键 词：睡眠呼吸暂停 阻塞性 呼吸暂停低通气指数 肾功能异常 

分 类 号：R766[医药卫生—耳鼻咽喉科]