肠三叶因子对胃肠道保护作用的研究进展  

Research Progress of protective effect of intestinal trefoil factor on the gastrointestinal tract

作　　者：薛翔[1] 聂时南[1] 

机构地区：[1]南京军区南京总医院急救医学科,南京医学硕士研究生210002

出　　处：《医学研究生学报》2014年第4期439-443,共5页Journal of Medical Postgraduates

基　　金：南京军区重大专项课题(12Z32)

摘　　要：肠三叶因子(trefoil factor,TFF3)是目前三叶因子家族(trefoil factor family)研究最多的一个,主要分布于肠道,具有胃肠道黏膜保护和上皮修复的作用,作用机制包括:与黏蛋白相互作用、迁移、抗凋亡、血管生成、免疫调节、与其受体相互作用等。"基因重组TFF3"已被批准为国家一类新药,主要用于修复黏膜、预防与治疗胃肠道溃疡及炎症。随着TFF3经典的受体及各级信号通路进一步明确,TFF3将会为成为胃肠道损伤性疾病有效的治疗手段。Intestinal trefoil factor （ITF or TFF3） is a member of trefoil factor family which is most studied , mainly in the in-testinal tract .TFF3 plays an important role in gastrointestinal mucosal protection and epithelial repair .Action mechanism includes in-teraction with mucin, migration, anti-apoptosis, angiogenesis, immune regulation, interaction with its receptor, etc.Recombinant TFF3 has been approved as a national drug and its therapeutic indications for repair mucosa , prevention and treatment of gastrointesti-nal ulcers and inflammation .Furthermore, the classic TFF3 receptor and signaling pathway is highly valuable to make TFF 3 become an effective treatment for gastrointestinal injury disease .

关 键 词：肠三叶因子 黏蛋白 迁移 免疫 黏膜 

分 类 号：R333.3[医药卫生—人体生理学]