舒洛地特联合双嘧达莫对慢性肾衰竭合并糖尿病患者动静脉内瘘术后的影响  

Effect of sulodexide combined with dipyridamole on postoperative period of internal arteriovenous fistulae in patients with chronic renal failure complicating diabetes

作　　者：欧阳南[1] 万梓鸣[1] 李正荣[1] 杜晓刚[1] 

机构地区：[1]重庆医科大学附属第一医院肾内科,400016

出　　处：《重庆医学》2014年第15期1863-1865,共3页Chongqing medicine

摘　　要：目的观察舒洛地特联合双嘧达莫对慢性肾衰竭合并糖尿病患者动静脉内瘘术后的影响。方法将72例慢性肾衰竭合并糖尿病患者分为两组:舒洛地特加双嘧达莫组(A组)和双嘧达莫组(B组),不同时间点检测血小板(PLT)、凝血象、血脂及血液流变学指标。观察动静脉内瘘术后内瘘通畅情况、内瘘成熟后的血流量、初次使用内瘘时间。结果 (1)A组患者动静脉内瘘通畅率较B组高。(2)与B组比较,A组患者纤维蛋白原(FIB)、全血黏度低切变率下降。(3)A组患者内瘘成熟时间较B组缩短,但动静脉内瘘血流量与B组差异无统计学意义。结论舒洛地特联合双嘧达莫用于慢性肾衰竭合并糖尿病患者预防动静脉内瘘术后血栓形成安全有效,疗效优于单用双嘧达莫。Objective To observe the effect of sulodexide combined with dipyridamole on postoperative period of internal arterio‐venous fistula in the patients with chronic renal failure complicating diabetes .Methods 72 cases of chronic renal failure complica‐ting diabetes were randomly divided into two groups ：sulodexide combined with dipyridamole group（group A） and dipyridamole group （group B） .Platelet ,fibrinogen（FIB） ,prothrombin time ,activated partial thromboplastin time ,triglyceride ,total cholesterol and hemortheological indexes were tested at different time points .The internal fistula patency ,blood flow volume after internal fis‐tula maturation and time of initial internal fistula use after internal arteriovenous fistula operationwere observed .‐Results （1）The patency rate of internal arteriovenous fistula in the group A was higher than that in the group B .（2） Compared with the group B , FIB and low‐shear rate of whole blood viscosity in the group A were decreased .（3）The time of internal fistula maturation in the group A was shortened ,but the blood flow volume had no significant difference between the two groups .Conclusion Sulodexide combined with dipyridamole is safe and effective for preventing the thrombogenesis after internal arteriovenous fistula operation ,its effect is superior to single dipyridamole .

关 键 词：肾功能衰竭  慢性 糖尿病 动静脉内瘘术 舒洛地特 双嘧达莫 

分 类 号：R692.5[医药卫生—泌尿科学]