ADA和IL-6对结核性胸膜炎的诊断价值  

Diagnostic Significanceof Adenosine Deaminase Activity and Interleukin- 6 in Tuberculous Pleural Effusions

作　　者：昝海峰[1] 谢文静[1] 陶绍华[1] 杨恂[1] 

机构地区：[1]成都大学附属医院呼吸科,四川成都610081

出　　处：《四川医学》2014年第5期588-591,共4页Sichuan Medical Journal

摘　　要：目的研究胸腔积液中腺苷脱氨酶(ADA)活性和白介素-6(IL-6)水平对结核性胸膜炎的诊断价值。方法分别用酶动力学检测和放射免疫法检测42例结核性胸膜炎、10例恶性胸腔积液、4例肺炎旁积液患者胸水中ADA活性和IL-6水平,并绘制受试者工作特征曲线(ROC曲线)评价2项指标对检测结核性胸膜炎的敏感性和特异性。结果结核性胸腔积液组胸水中ADA和IL-6水平均显著高于非结核性胸腔积液组。ROC曲线显示2项指标中ADA具有较高的敏感性和特异性。结论胸腔积液中ADA和IL-6水平测定有助于结核性胸膜炎的诊断。Objective The research of Pleural fluid adenosine deaminase（ADA） activity and interleukin-6（IL-6） levels on the diagnosis of tuberculous pleurisy.Methods Enzyme kinetics were used to detect and radioimmunoassay in 42 patients with tuberculous pleurisy,10 cases of malignant pleural effusion,four cases of patients with parapneumonic pleural effusion ADA activity and IL-6 levels measured and plotted receiver operating characteristic curve（ROC curve） evaluated two tuberculous pleurisy index detection sensitivity and specificity.Results Tuberculous pleural effusion pleural fluid ADA and IL-6 levels were significantly higher than nontuberculous pleural effusion.ROC curve shows two indicators ADA has a high sensitivity and specificity.Conclusion Pleural effusion ADA and IL-6 levels were measured to help diagnose tuberculous pleurisy.

关 键 词：结核性胸膜炎 腺苷脱氨酶 白介素-6 

分 类 号：R521.7[医药卫生—内科学]