维生素D缺乏与儿童脓毒症  

Vitamin D deficiency in septic children

作　　者：钱素云[1] 

机构地区：[1]首都医科大学附属北京儿童医院,100045

出　　处：《国际儿科学杂志》2014年第3期324-330,共7页International Journal of Pediatrics

基　　金：首都卫生发展科研专项项目（项目号：2011-2009-01）;十二五国家科技重大专项课题（项目号：2012BAI04B00）

摘　　要：维生素D缺乏和脓毒症是世界性的健康问题.维生素D的生物多效性提示其可能在脓毒症发生发展中发挥作用.脓毒症时,局部免疫反应以及全身炎症途径激活,可能成为维生素D治疗的靶点.临床研究发现呼吸道感染、危重症及脓毒症时伴维生素D缺乏.但是,脓毒症与维生素D缺乏因果关系尚不明确.Vitamin D deficiency and sepsis are both worldwide problems with health consequences. The pleiotropic actions of vitamin D might synergistically influence pathogenesis of sepsis. Sepsis is associated with local immune responses to pathogens and the activation of systemic inflammatory pathways, which may be the novel targets of vitamin D activity. Clinical observational trials have found vitamin D deficiency is associated with respiratory infections, critical illness and sepsis. The causal relationship has yet to be clearly defined.

关 键 词：维生素D 脓毒症 儿童 

分 类 号：R720.597[医药卫生—急诊医学]