小脑上脚交叉的各向异性分数和表观弥散系数值与年龄、性别的相关性研究  

Fractional anisotropy and apparent diffusion coefficient values of the decussation of superior cerebellar peduncle on diffusion tensor imaging: correlation with age and gender

作　　者：马得廷[1] 王君霞[2] 孔庆奎[1] 谢元忠[1] 

机构地区：[1]山东省泰安市中心医院医学影像部,271000 [2]山东省泰安市中心医院产科,271000

出　　处：《中华临床医师杂志（电子版）》2014年第3期56-61,共6页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的量化比较不同年龄段小脑上脚交叉的各向异性分数（FA）值和与表观弥散系数（ADC）值,并探讨小脑上脚交叉的FA值、ADC值与年龄、性别的相关性。方法回顾性分析100例正常人群横轴位弥散张量成像（DTI）图像,其中男女各50例,年龄30~79岁,平均54.7岁。由一名专家运用感兴趣区（ROI）功能在FA图和ADC图上分别测量小脑上脚交叉的FA值和ADC值。配对或独立样本t检验比较性别间的差异,单因素方差分析用于各年龄组之间的差异,双变量相关用于分析年龄对小脑上脚交叉信号的影响或相关性。结果 100例健康成年人中,小脑上脚交叉的FA值（0.52±0.04）明显低于小脑上脚的FA值（0.71±0.05）,差异具有统计学意义（t=-36.718,P=0.000）。其中小脑上脚交叉的男性和女性FA值分别为0.52±0.04和0.51±0.04,无统计学差异（t=1.404,P=0.164）。经双变量相关分析,小脑上脚交叉的FA值与年龄呈低度正相关（r=0.300,P=0.002）。小脑上脚交叉和小脑上脚的ADC值分别为（722.23±38.75）×10^-6 mm^2/s和（759.16±31.23）×10^-6 mm^2/s,有统计学差异（t=-8.047,P=0.000）。小脑上脚交叉的女性ADC值为（725.98±35.04）×10^-6 mm^2/s,虽然高于男性ADC值[（718.48±42.16）×10^-6 mm^2/s],但无统计学差异（t=-0.967,P=0.336）。经双变量相关分析,小脑上脚交叉的ADC值与年龄无相关性（r=-0.076,P=0.451）。结论在DTI图像中,小脑上脚交叉的FA值和ADC值均低于小脑上脚,并且均与性别没有相关性。随着年龄增大,FA值呈现增高趋势,ADC值则与年龄无相关性。本研究的结果可为今后的相关研究提供参考。Objective To compare with the fractional anisotropy（FA） and apparent diffusion coefficient（ADC） values of decussation of superior cerebellar peduncle（DSCP） between age groups and investigate relationship between FA and ADC value of the DSCP and age and gender in healthy subjects. Methods Axial FA maps and ADC maps of 100 neurologically normal subjects（50 men, 50 women; age range： 30-79 years, mean age： 54.7 years） using diffusion tensor imaging（DTI） were evaluated retrospectively. Measurement of the FAs and ADC values was done by one radiologist and by placing circular ROIs in the DSCP and SCPs. Independent-Sample t-test was used to evaluate the gender difference of FA and ADC values of DSCP. Difference of age groups was used one-way analysis of variance（ANOVA）, and bivariate correlation analysis were performed to evaluate the effects of gender and age, and pearson correlation coefficient（r） was obtained. Results In 100 healthy patients, the FA value was significantly lower in the DSCP（0.52±0.04） than in the SCP（0.71±0.05）, the difference was significant（t=-36.718, P=0.000）. There were not significant difference（t=1.404, P=0.164） between males（0.52±0.04） and females（0.51±0.04） on the FA value of DSCP. The FA value of DSCP significantly positively correlated with patients＇ age（r=0.300, P=0.002） by bivariate correlation. The ADC value was significantly lower in the DSCP[（722.23±38.75）×10^-6 mm^2/s] than in the SCP [（759.16±31.23） ×10^-6 mm^2/s]; the difference was significant（t=-8.047, P=0.000）. The ADC value of DSCP tended to be higher in females [（725.98±35.04）×10^-6 mm^2/s] than in males [（718.48±42.16）×10^-6 mm^2/s]; however, this difference was not significant（t=-0.967, P=0.336）. The ADC value of DSCP was not correlation with patients＇ age（r=-0.076, P=0.451） by bivariate correlation. Conclusions Both FA and ADC values of the DSCP were lower than those of the SCP which showed no correlation with gender. FA va

关 键 词：各向异性 磁共振成像 弥散 表观弥散系数 小脑上脚交叉 

分 类 号：R445.1[医药卫生—影像医学与核医学]