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机构地区:[1]云南省昭通市第一人民医院,云南昭通657000
出 处:《中国医学创新》2014年第14期16-18,共3页Medical Innovation of China
摘 要:目的:观察口服制剂布洛芬对早产儿动脉导管未闭(PDA)的治疗疗效和不良反应。方法:选择符合入选标准的早产儿PDA 106例,给予口服布洛芬混悬滴剂,每24小时给药一次,剂量分别为(10-5-5)mg/kg。用药期间和结束后监测PDA关闭情况、循环功能、肾功能、出凝血功能和颅内出血发生情况。结果:(1)经治疗99例(99/106,93.4%)PDA关闭。(2)疗效与胎龄有关,胎龄≥34周疗效为96.4%(54/56),优于胎龄<34周的疗效90%(45/50),差异有统计学意义(P<0.05)。出生体质量≥2000 g疗效与出生体质量<2000 g相当,分别为94.2%(49/52)和92.6%(50/54),差异无统计学意义(P>0.05)。(3)不良反应表现为一过性少尿(46.2%),肌酐和尿素水平正常。未发现血小板减少。早产儿喂养不耐受发生率为29.2%,程度较轻,未出现坏死性小肠结肠炎。未发现颅内出血加重。结论:口服布洛芬可以关闭早产儿动脉导管未闭,近期不良反应发生率较低。但尚需观察其远期不良反应,以评价其安全性。Objective: To study efficacy and safety of oral ibuprofen ( Motrin suspension ) in the treatment of preterm infant with patent ductus arteriosus ( PDA ) . Method: A total of 106 preterm infants with PDA were included 3 to 18 days after birth. The patients were orally administered ibuprofen, and the doses were 10-5-5 mg/kg every 24 hours. Monitoring PDA closure rate, circulatory function, renal function, blood coagulation and the incidence of intracraniaq hemorrhage were taken before and after the treatment. Result: ( 1 ) 99 patients ( 99/106, 93.4% ) got the closure of PDA. ( 2 ) The efficacy was related to the GA. The higher closure rate was in the newborns with GA 1〉 34 weeks ( 54/56, 96.4% ) than ones with GA 〈 34 weeks ( 45/50, 90% ), P〈0.05. There were no significantly differences in the closure rate between the BW≥2000 g group ( 49/52, 94.2% ) and BW 〈2000 g group ( 50/54, 92.6% ), P〉O.05. ( 3 ) Side effects manifested as a transient oliguria ( 46.2% ), creatinine and urea levels were normal. No thrombocytopenia. Feeding intolerance in preterm children was 29.2%, to a lesser extent, necrotizing enterocolitis does not appear. Aggravation of intracranial hemorrhage was not found. Conclusion: The efficacy and safety of administration of oral ibuprofen for treating PDA in preterm infants are acceptable. However, pharmacokinetics and clinical controlled trials are needed in the future in preterm infants to provt, the therapeutic effect and make the efficient regimen.
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