MRI示踪技术在心梗干细胞移植治疗中的应用现状  

The application of magnetic resonance cell tracing technique in myocardial infarction cell transplantation treatment

作　　者：崔辰 赵世华 

机构地区：[1]中国医学科学院北京协和医院国家心血管病中心阜外心血管病医院心血管疾病国家重点实验室,北京100037

出　　处：《磁共振成像》2014年第3期222-226,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金重点项目(编号:81130029)

摘　　要：干细胞移植是治疗心肌梗死的新策略,MRI既可以提供心血管详细解剖结构和功能信息,还能有效地示踪细胞,从而更好的监测和观察细胞移植的情况。目前常规的示踪方法是通过超顺磁性氧化铁颗粒直接标记细胞,这种示踪方式可以确定细胞移植的在体内的分布,然而其特异性较差,不能反映细胞的存活情况。而MRI报告基因成像在一定程度上避免了传统超顺磁性氧化铁直接标记细胞示踪法的劣势,可以验证细胞的存活,通过这种方法可以更深入的认识移植细胞的存活和分化情况。Stem cell transplantation has the potential to treat myocardial infarction. MRI is emerging as a robust tool to provide anatomical and functional information of patient with cardiovascular disease, but also plays an important role in tracing graft cells. SPIO is one of the most widely used probes, which can identify the graft site accurately. However, the presence of SPIO cannot guarantee the survival of the stem cells and this limits its use. The MRI reporter gene imaging technique can fill this gap to access the survival information of the grafted cells and help researchers to achieve a higher level of understanding of the fate of the cell.

关 键 词：磁共振成像 超顺磁性氧化铁颗粒 报告基因成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R542.22[医药卫生—诊断学]