新肾显像剂^(99m)Tc-TTHA的制备和生物分布  

THE PREPARATION AND BIO DISTRIBUTION OF NEW KIDNEY IMAGING AGENT ^(99m)Tc-DTPA

作　　者：宋文娇[1] 吴战宏[1] 王学斌[1] 陆丽仪[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《北京师范大学学报（自然科学版）》2001年第1期92-95,共4页Journal of Beijing Normal University(Natural Science)

摘　　要：对三乙四胺六醋酸 (TTHA)的99mTc标记条件以及冻干药盒的制备进行了初步研究 ,并将TTHA药盒与DTPA药盒 (二乙三胺五醋酸 )的小鼠生物分布结果进行了比较 .找到了在近中性条件下 (pH =6～ 7)的最佳标记条件 ,并获得较高的标记率 (98%～ 99% ) .TTHA药盒与DTPA药盒的小鼠生物分布研究表明 ,2种药盒的生物分布和动力学性质是相似的 ,但从相同时相的肾摄取和清除数据看99mTc TTHA在 1min的肾摄取率为 2 9.6 0 %·g- 1,半减期 2 .8min ,而99mTc DTPA在 1min的肾摄取率为 2 8.88%·g- 1,半减期 4 .5min .因此 ,99mTc TTHA略优于99mTc DTPA 。Labelling condition with 99m Tc and kit preparation of triethylene tetraminehexaacetic acid (TTHA) are preliminarily studied. The bio distribution of TTHA kit is compared with that of DTPA kit. The best condition of TTHA labeling in neutral solution (pH=6～7) is found, and the labeling yield is above 98%. Bio distribution studies in mice show that the behavior of TTHA kit and DTPA kit is very similar. But compared the data carefully, 99m Tc TTHA is a littler better than 99m Tc DTPA. Further study is needed.

关 键 词：肾显像剂 99mTc标记放射性药物 三乙四胺六醋酸 制备 冻干药盒 生物分布 标记率 

分 类 号：TQ463.7[化学工程—制药化工] R817.9[医药卫生—影像医学与核医学]