亚临床甲状腺功能减退对2型糖尿病患者下肢动脉病变的影响  

Study on Relationship of Subclinical Hypothyroidism and Peripheral Vascular Disease in Patients with Type 2 Diabetes Mellitus

作　　者：池潇 段琦[2] 王利民[2] 尹洁[2] 洪旭[2] 

机构地区：[1]内蒙古乌拉特中旗人民医院,内蒙古海流图015300 [2]北京友谊医院,北京100000

出　　处：《内蒙古医学杂志》2014年第4期420-422,共3页Inner Mongolia Medical Journal

摘　　要：目的探讨亚临床甲状腺功能减退(甲减)对2型糖尿病患者下肢动脉病变的影响。方法 2012年6月至2013年6月于北京友谊医院住院治疗的2型糖尿病140例,其中男性72例,女性68例。甲状腺功能正常组78例,亚临床甲减组62例。所有病例均行多普勒超声检查ABI。测定FT3、FT4、TSH、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、载脂蛋白-A1、载脂蛋白B、糖化血红蛋白、空腹胰岛素水平。结果合并亚临床甲减的2型糖尿病患者下肢动脉病变发生率明显增加。糖尿病合并甲状腺功能正常组中PAD发病率为10.2%,糖尿病合并亚临床甲减组中PAD发病率为33.8%,两组经χ2检验,差异有统计学意义。结论亚临床甲减可增加2型糖尿病患者下肢动脉病变的发生率。Objective To investigate on the relationship of subclinical hypothyroidism and peripheral vascular disease in patients with type 2 diabetes mellitus. Methods A total of 140 type 2 diabetic patients（ 78 patients without subclinical hypothyroidism and 62 patients with subclinical hypothyroidism）,admit ted to our hospital from Jun 2012 to Jun 2013 were included in our study. ABI was determined with ultrasound. FT3、FT4、TSH、fasting plasma glucose、total cholesterol、low density lipoprotein cholesterol、high density lipoprotein cholesterol、triglyceride、APOA1、APOB、glycosylated hemoglobin and fasting insulin were measured. Results The mortality of peripheral vascular disease with subclinical hypothyroidism is significantly higher than that without subclinical hypothyroidism（ P〈0. 01）. Conclusion Subclinical hypothyroidism may lead to an increase in peripheral vascular disease in patients with type 2 diabetes mellitus.

关 键 词：亚临床甲状腺功能减退 2型糖尿病 下肢动脉病变 

分 类 号：R581[医药卫生—内分泌]