青蒿素及其衍生物的电化学性质研究Ⅱ——氯化血红素存在下的青蒿素还原机理  

Study on the Electrochemical Behaviors of Artemisinin(Qinghaosu) and Its Derivatives Ⅱ Reduction Mechanism of Artemisinin in the Presence of Hemin

作　　者：陈扬[1] 朱世民[1] 陈洪渊[2] 

机构地区：[1]东南大学分子与生物分子电子学教育部重点实验室,南京210096 [2]南京大学化学系,南京210093

出　　处：《北京大学学报（自然科学版）》2001年第2期255-260,共6页Acta Scientiarum Naturalium Universitatis Pekinensis

基　　金：国家自然科学基金;中国科学院长春应化所电分析开放实验室资助项目

摘　　要：用电化学方法研究了青蒿素与氯化血红素之间的相互作用。青蒿素在玻璃碳电极上于- 1.0 8V处能发生一个 2电子转移的不可逆还原。即使在低至 4 .0× 10 - 8mol/L氯化血红素存在下 ,青蒿素仍可被催化还原 ,阴极过电位降低了 6 0 0mV。配合物EDTA Fe(Ⅲ )具有类似氯化血红素的催化性质 ,它降低了QHS阴极过电位 590mV。在这个体系中 ,青蒿素在碳电极上的还原是一个借助于氯化血红素催化的还原过程 ,氯化血红素的存在降低了青蒿素还原活化能 ,促进了青蒿素的分解。The interaction between artemisinin and hemin was investigated by electrochemical methods.Artemisinin was irreversibly reduced at -1.08?V via a two\|electron transfer at the glassy carbon electrode.In the presence of concentration of hemin as low as 4.0×10 -8 ?mol/L,artemisinin can be reduced via the hemin\|catalysis and its original cathodic peak at -1.08?V completely disappeared.The cathodic overpotential of artemisinin is decreased ca.600?mV.This process is verified by the fact that complex EDTA\|Fe(Ⅲ) can also promote the artemisinin reduction with decreasing the cathodic overpotential of artemisinin for 590?mV.These results show that the reduction of artemisinin at the glassy carbon electrode is a catalytic process with the aids of hemin.Hemin can greatly decrease the cathodic activation energy of the reduction of artemisinin and promote the decomposition of artemisinin.

关 键 词：青蒿素 氯化血红素 催化还原 中草药 还原机理 电化性质 抗疟药 阴极过电位 

分 类 号：O657.1[理学—分析化学]