参松养心胶囊对原发性失眠患者睡眠脑电图的影响  

Shensongyangxin capsule on sleep EEG in patients with primary insomnia

作　　者：夏光明[1] 黄虎翔[2] 王洲羿[2] 吴红南[1] 金朝霞[1] 陈浩特[1] 李刚[1] 

机构地区：[1]长江大学附属黄冈市中心医院全科医学科,438000 [2]长江大学附属黄冈市中心医院神经内科,438000

出　　处：《疑难病杂志》2014年第5期513-516,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察参松养心胶囊对原发性失眠患者睡眠脑电图的影响。方法 原发性失眠患者80例随机分为对照组和观察组,各40例,2组均给予心理治疗和行为干预。对照组在此基础上加服谷维素2片/次,每天3次;观察组给予参松养心胶囊,4粒/次,每天3次,疗程4周。用多导睡眠图描记技术评价该药物临床疗效。结果与治疗前比较,治疗组治疗后睡眠潜伏期明显缩短[(24.74±14.56)min vs.(32.65±18.29)min,P<0.01],觉醒次数和觉醒时间明显减少[(4.67±1.97)次vs.(6.26±2.01)次,(24.56±8.56)min vs.(56.65±7.23)min,P<0.01],总睡眠时间及睡眠效率明显提高[(334.85±84.71)min vs.(284.26±76.56)min,(81.24±17.30)%vs.(74.32±16.48)%,P<0.01)];睡眠结构分析,慢波睡眠中浅睡较前减少,尤其S1期睡眠明显[(9.36±5.01)%vs.(17.56±3.47)%,P<0.01],而深睡(S3+S4期)显著改变[(20.15±2.00)%vs.(10.45±1.35)%,P<0.05],快速眼动睡眠潜伏期显著减少[(87.54±34.37)min vs.(108.25±39.49)min,P<0.05]。对照组除睡眠潜伏期减少外,其余参数均无变化。治疗组与对照组匹兹堡睡眠质量量表评分均较治疗前改善,且治疗组优于对照组,差异有统计学意义(P<0.05),总有效率比较,差异有统计学意义(95.0%vs.65.0%,P<0.01);2组间不良反应发生率比较差异无统计学意义(10.0%vs.7.5%,P>0.05)。结论参松养心胶囊治疗原发性失眠疗效确切,可明显改善睡眠脑电图,值得临床推广应用。Objective To study the changes of polysomnograms in patients with primary insomnia treated with Shensongyangxin capsule.Methods 80 patients with primary insomnia were randomly divided into control group and observation group with 40 cases in each group;two groups were given psychotherapy and behavioral interventions.The control group with oryzanol 2 tablets/time,tid;observation group were given Shensongyangxin capsule,4 tablets/time,tid.4 weeks later to evaluate the clinical efficacy of the drug with polysomnography tracings technology.Results Compared with before treatment,after treatment,sleep latency was significandy shorter[（24.74±14.56） min vs.（32.65±18.29） min,P〈0.01],number of awakenings and awakening time was significantly reduce[（4.67±1.97） times vs.（6.26±2.01） times,（24.56±8.56） vs.（56.65±7.23） min,P〈0.01],total sleep time and sleep efficiency improved significantly（334.85±84.71）min vs.（284.26±76.56） min,（81.24±17.30）%vs.（74.32±16.48）%,P〈0.01｜;sleeping structural analysis revealed that slow-wave sleep,light sleep less than before treatment,especially in S1 sleep[（9.36±5.01）%vs.（17.56±3.47）%,P〈0.01],and deep sleep（S3＋S4 period） changed significandy[（20.15±2.00）%vs.（10.45±1.35）%,P〈0.05],significandy reduced REM latency of sleepy[（87.54±34.37） vs.（108.25±39.49）,P〈0.05].In addition to reducing sleep latency in control group,the other parameters were not changed.Compared with before treatment,the Pittsburgh sleep quality scores in treatment group and the control group were improved,and the treatment group better than the control group,the difference was statistically significant（P〈0.05）,total effective rate,the difference was statistically significant（95.0%V9.65.0%,P〈0.01）;the incidence of adverse reactions in the 2 groups was showed no significant difference（10.0%vs.7.5%,P〉0.05）.Conclusion Shensongyangxin capsule could improve the sleep EEG and sleep quality of the patients with primary inso

关 键 词：参松养心胶囊 失眠 原发性 睡眠脑电图 

分 类 号：R256.23[医药卫生—中医内科学]