探讨 Graves 病甲亢患者 TPOAb 和 TGAb 含量与手术治疗后甲减的关系  

Correlation Between Serum Levels of TPOAb and TGAb in Patients with Graves Hyperthyroidism and the Incidence of Hypothyroidism after Subtotal Thyroidectomy

作　　者：李洲成[1] 伍石华[1] 向元楚[1] 钟荣国[1] 石斌[1] 周铁兴 王鑫[1] 

机构地区：[1]邵阳医学高等专科学校附属医院甲乳外科,湖南邵阳422000

出　　处：《医学临床研究》2014年第4期656-658,共3页Journal of Clinical Research

基　　金：湖南省科技厅基金资助（2011SK3032）

摘　　要：【目的】测定手术治疗前Graves病甲状腺功能亢进（甲亢）患者血清甲状腺过氧化物酶抗体（ T POAb）和甲状腺球蛋白抗体（ TGA b）水平，探讨其在手术治疗后与甲状腺功能减退（甲减）发生的关系。【方法】根据手术治疗前TPOA b、TGA b的检测结果，将198例患者分成3组：双阴组12例，单阳组32例，双阳组154例，比较各组间甲减的发生率。再将双阳组的154例患者，按TPOA b、TGA b滴度水平的高低分成3组：A组79例，B组65例，C组10例，进一步探讨手术治疗前TPOA b、TGA b滴度水平的高低与甲减的关系。【结果】手术治疗后甲减发生率差异有统计学意义（ P＜0．005）。双阳组的154例患者，其TPOAb、TGA b滴度水平高低与甲减发生率相关（ P＜0．005）。【结论】TGAb、TPOA b滴度水平的检测对于甲亢手术治疗后甲减的预测有指导作用。[Objective]To measure serum levels of thyroid peroxidase antibody （TPOAb ） and thyroglobulin antibody （TGAb） in patients with Graves hyperthyroidism before surgery ,and to explore their correlation with the incidence of hy-pothyroidism after surgery .[Methods]According to the results of TPOAb and TGAb ,198 patients were divided into both negative TPOAb and TGAb group（ n=12） ,positive TPOAb or TGAb group（ n = 32） and both positive TPOAb and TGAb（ n=154） .According to the titer levels of TPOAb and TGAb ,154 patients with both positive TPOAb and TGAb were also divided into group A （ n=79） ,group B（ n=65） and group C（ n=10） .The correlation of the titer levels of TPOAb and TGAb with hypothyroidism before the operation was further discussed .[Results] There was significant difference in the incidence of hypothyroidism after the operation among three groups （ P〈0 .005） .Among 154 patients of both positive TPOAb and TGAb group ,the titer levels of TPOAb and TGAb were related with the incidence of hyperthy-roidism（ P〈0 .005） .[Conclusion] The detection of serum levels of TPOAb and TGAb is of significance for predicting the incidence of hypothyroidism after surgery .

关 键 词：甲状腺功能亢进症 抗体 甲状腺功能减退症 格雷夫斯病 

分 类 号：R581.1[医药卫生—内分泌]