探讨 Graves 病甲亢患者 TPOAb 和 TGAb 含量与手术治疗后甲减的关系  被引量:3

Correlation Between Serum Levels of TPOAb and TGAb in Patients with Graves Hyperthyroidism and the Incidence of Hypothyroidism after Subtotal Thyroidectomy

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作  者:李洲成[1] 伍石华[1] 向元楚[1] 钟荣国[1] 石斌[1] 周铁兴 王鑫[1] 

机构地区:[1]邵阳医学高等专科学校附属医院甲乳外科,湖南邵阳422000

出  处:《医学临床研究》2014年第4期656-658,共3页Journal of Clinical Research

基  金:湖南省科技厅基金资助(2011SK3032)

摘  要:【目的】测定手术治疗前Graves病甲状腺功能亢进(甲亢)患者血清甲状腺过氧化物酶抗体( T POAb)和甲状腺球蛋白抗体( TGA b)水平,探讨其在手术治疗后与甲状腺功能减退(甲减)发生的关系。【方法】根据手术治疗前TPOA b、TGA b的检测结果,将198例患者分成3组:双阴组12例,单阳组32例,双阳组154例,比较各组间甲减的发生率。再将双阳组的154例患者,按TPOA b、TGA b滴度水平的高低分成3组:A组79例,B组65例,C组10例,进一步探讨手术治疗前TPOA b、TGA b滴度水平的高低与甲减的关系。【结果】手术治疗后甲减发生率差异有统计学意义( P<0.005)。双阳组的154例患者,其TPOAb、TGA b滴度水平高低与甲减发生率相关( P<0.005)。【结论】TGAb、TPOA b滴度水平的检测对于甲亢手术治疗后甲减的预测有指导作用。[Objective]To measure serum levels of thyroid peroxidase antibody (TPOAb ) and thyroglobulin antibody (TGAb) in patients with Graves hyperthyroidism before surgery ,and to explore their correlation with the incidence of hy-pothyroidism after surgery .[Methods]According to the results of TPOAb and TGAb ,198 patients were divided into both negative TPOAb and TGAb group( n=12) ,positive TPOAb or TGAb group( n = 32) and both positive TPOAb and TGAb( n=154) .According to the titer levels of TPOAb and TGAb ,154 patients with both positive TPOAb and TGAb were also divided into group A ( n=79) ,group B( n=65) and group C( n=10) .The correlation of the titer levels of TPOAb and TGAb with hypothyroidism before the operation was further discussed .[Results] There was significant difference in the incidence of hypothyroidism after the operation among three groups ( P〈0 .005) .Among 154 patients of both positive TPOAb and TGAb group ,the titer levels of TPOAb and TGAb were related with the incidence of hyperthy-roidism( P〈0 .005) .[Conclusion] The detection of serum levels of TPOAb and TGAb is of significance for predicting the incidence of hypothyroidism after surgery .

关 键 词:甲状腺功能亢进症 抗体 甲状腺功能减退症 格雷夫斯病 

分 类 号:R581.1[医药卫生—内分泌]

 

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