胃管注入解磷啶及甘露醇应用于有机磷农药中毒的临床效果  

Clinical Efficacy of Stomach Tube Injection of Pralidoxime Iodide and Mannitol Applied in Or-ganophosphorus Pesticide Poisoning

作　　者：尤静[1] 石咏梅[1] 石红梅[1] 

机构地区：[1]江苏省泰兴市人民医院急诊中心,江苏泰兴225400

出　　处：《医学临床研究》2014年第4期715-717,共3页Journal of Clinical Research

摘　　要：【目的】探讨胃管注入解磷啶及甘露醇应用于有机磷农药中毒患者的临床效果。【方法】将60例有机磷农药中毒患者分为观察组32例及对照组28例。对照组给予常规洗胃、阿托品化、解磷啶注射、补液、对症治疗；观察组在上述治疗的基础上，于洗胃管中注入解磷啶（或氯磷啶）及甘露醇，比较两组治疗的临床效果。【结果】观察组阿托品用量、反跳人数明显少于对照组（P〈0．01），而达阿托品化时间、住院时间、治愈率、病死率等方面均优于对照组（P〈0．05）。【结论】及早于洗胃管中注入解磷啶（或氯磷啶）及甘露醇，可明显提高有机磷农药中毒的抢救成功率。[Ohjective] To explore clinical efficacy of stomach tube injection of pralidoxime iodide and mannitol applied in patients with organophosphorus pesticide poisoning. [Methods] Totally 60 patients with organophosphorus pesticide poisoning were randomly divided into observation group（ n= 32） and control group（ n = 28）. The control group was given routine gastric lavage, atropine, pralidoxime iodide injection, fluid infusion and symptomatic treat- ment. The observation group was given gastric lavage tube injection of pralidoxime iodide（or chlorophus） and manni- tol based on the above treatment. Clinical efficacy was compared between two groups. [Results] Atropine dosage and the frequency of bounce in observation group were obviously less than those in control group（ P 〈0. 01）, while atro- pinization time, hospitalization time, curative rate and mortality in observation group were better than those in control group（ P 〈0.05）. [Conclusion] Early gastric lavage tube injection of pralidoxime iodide（or chlorophos） and mannitol can obviously improve the rescue successful rate of organophosphorus pesticide poisoning.

关 键 词：有机磷化合物 中毒 解磷定化合物/投药和剂量 甘露醇/投药和剂量 

分 类 号：R595.4[医药卫生—内科学]