Vancomycin and glycopeptide-resistant enterococci  

作　　者：Gary FRENCH 

机构地区：[1]King's College and Guy's and St Thomas' Hospital,London, UK, London SEI 7EH UK

出　　处：《中国感染与化疗杂志》2014年第3期249-256,共8页Chinese Journal of Infection and Chemotherapy

摘　　要：Enterococci are important causes of community and healthcare-associated infections and are associated with hospital outbreaks amongst vulnerable and compromised patients.These organisms have relatively low virulence but are inherently antibiotic resistant.They readily acquire additional multiple resistances,including resistance to the glycopeptides vancomycin and teicoplanin.Such resistance severely limits antibiotic choice and leads to poor clinical outcomes.New antibiotics are becoming available for the treatment of glycopeptideresistant enterococci,but there is limited data on their clinical effectiveness and the choice of therapy remains problematic.In addition,glycopeptide resistance can transfer from enterococci to the much more virulent methicillin-resistant Staphylococcus aureus(MRSA),although this has so far occurred infrequently.In order to limit the emergence and spread of glycopeptide-resistant enterococci and glycopeptide resistant MRSA,it is essential for hospitals to implement appropriate and effective systems of infection control and antimicrobial stewardship.Summary Enterococci are important causes of communi- ty and healthcare-associated infections and are as- sociated with hospital outbreaks amongst vulnera- ble and compromised patients. These organisms have relatively low virulence but are inherently an- tibiotic resistant. They readily acquire additional multiple resistances, including resistance to the glycopeptides vancomycin and teicoplanin. Such resistance severely limits antibiotic choice and leads to poor clinical outcomes. New antibiotics are be- coming available for the treatment of glycopeptide- resistant enterococci, but there is limited data on their clinical effectiveness and the choice of therapy remains problematic. In addition, glycopeptide re- sistance can transfer from enterococci to the much more virulent methicillin-resistant Staphylococcus aureus （MRSA）, although this has so far occurred infrequently. In order to limit the emergence and spread of glycopeptide-resistant enterococci and glycopeptide resistant MRSA, it is essential for hospitals to implement appropriate and effective systems of infection control and antimicrobial stewardship.

关 键 词：医院感染 预防与控制 细菌耐药 机制研究 

分 类 号：R515[医药卫生—内科学]