人参皂苷Rd的抗癌机制研究进展  

Advances in the Research of Antitumor Mechanism of Ginsenoside Rd

作　　者：朱春燕[1] 张旭[1] 叶丽红[1] 

机构地区：[1]南京中医药大学,江苏南京210029

出　　处：《中医药学报》2014年第2期81-86,共6页Acta Chinese Medicine and Pharmacology

基　　金：国家科技支撑计划"中医药诊疗技术及特色产品应用研究"重点项目(2006BA I 11B08);江苏省高校优势学科建设工程资助项目(PAPD)

摘　　要：人参皂苷Rd是二醇型人参皂苷在人体肠道内的主要代谢产物之一,是三七、人参、绞股蓝等的提取物,具有广泛的生物活性。对心脑血管、神经系统、免疫系统及抗肿瘤方面等作用独特。由于人参皂苷Rd的药理作用的多样性和安全性,已成为人们关注的焦点,但因人参皂苷Rd的结构复杂,化学合成至今尚未成功,需从植物药中提取以满足医疗和科研的需要,但因植物中人参皂苷Rd的量较低,从植物中提取的方法难以满足需要。因此,国内外着重对有效获取人参皂苷Rd方面进行了大量研究,而忽略了其本身的抗癌功效。肿瘤防治现已成为世界性难题,据专家预测,由于我国目前环境污染和吸烟问题仍然严重,在2025年前癌症总的发病率不大可能下降,所以癌症是一个必须面对的多发病、常见病,而人参皂苷Rd由于其天然、价廉、低毒性,且在诱导癌细胞凋亡方面疗效显著,为抗癌药物新药开发提供了新的道路。故本文对人参皂苷Rd的抗癌机制研究进行了详细综述,旨在为人参皂苷Rd防治肿瘤及放化疗毒副反应提供理论依据。Ginsenoside Rd is one of the main metabolites in the human gut,which belongs to the panaxadiol group of dammarane glycosides. Ginsenoside Rd is extracted from notoginseng,ginseng,gynostemma etc,which has extensive biological activity. It has a unique effect on heart cerebrovascular,nervous system,immune system and antitumor. The treatment and prevention of tumour have been a worldwide problem. Due to the diversity and security of the pharmacological effects of Rd,it has become the focus of attention. The chemical synthesis of ginsenoside Rd has not been successful because of the complicated structure. It is extracted from plants to meet the needs of the medical and scientific research. But because the amount of ginsenoside Rd extracted from plants is low,it is difficult to meet the need. Therefore,both domestic and overseas focus on the effective extracted way ginsenosides and ignore its anti- cancer effect. Therefore,both at home and abroad we focus on the effective access to a lot of work on ginsenoside Rd and ignore its anti- cancer effect. Therefore,this paper researches on the antitumor mechanism in detail in order to provide theoretical basis for ginsenoside Rd to treat tumor and the toxic and side effect of radiotherapy and chemotherapy.

关 键 词：人参皂苷RD 肿瘤 细胞凋亡 瞬时受体电位通道7 泛素-蛋白酶系统 

分 类 号：R285[医药卫生—中药学]