^(99)Tc^mN-NOET SPECT亲肿瘤显像鉴别诊断甲状腺结节良恶性  

^(99)Tc^mN-NOET SPECT in differential diagnosis of thyroid nodule

作　　者：刘海燕[1] 李雁杰[2] 王进[1] 胡光[1] 武志芳[1] 刘建中[1] 程艳[1] 卫华[1] 李思进[1] 

机构地区：[1]山西医科大学第一临床医学院核医学科,太原030001 [2]山西医科大学第一临床医学院眼科

出　　处：《山西医科大学学报》2014年第5期377-381,共5页Journal of Shanxi Medical University

基　　金：山西省基础研究青年科技研究基金资助项目(2012021030-2);山西省卫生厅科技攻关计划资助项目(20100115)

摘　　要：目的探讨99TcmN-NOET SPECT亲肿瘤显像及其半定量指标诊断甲状腺"冷、凉"结节良、恶性的价值。方法 33例患者术前2周行99TcmO4-甲状腺常规扫描,显示为单个"冷、凉"结节的患者隔日行99TcmN-NOET显像。显像后行手术并获得病理结果。结节分析采用肉眼分析和半定量指标—靶非靶比值(tumor/normal tissue,T/N)。结果①根据术后病理结果分为恶性组和良性组。恶性组16例,男/女为1/15,年龄24-78岁,平均(51.81±15.34)岁;有乳头状癌5例,滤泡状癌9例,髓样癌2例。良性组17例均为腺瘤,男/女为2/15,年龄23-78岁,平均(49.65±12.24)岁。②16例甲状腺癌患者中NOET填充的有14例,部分填充2例。16例甲状腺癌NOET评分2分10例,3分6例,总得分为38分。17例良性病变中,15例为NOET阴性,2例假阳性病例为周边填充,中央未见填充。③甲状腺癌的NOET T/N值为1.57±0.38,甲状腺腺瘤为1.05±0.36,良、恶性组间比较,差异有统计学意义(t=16.095,P<0.001)。结论99TcmN-NOET SPECT亲肿瘤显像及其半定量指标对鉴别诊断甲状腺结节良、恶性有较大临床价值。Objective To explore the value of99TcmN- NOET SPECT in diagnosis of benign and malignant of thyroid＂cool or cold＂ nodules. Methods99TcmN- NOET SPECT was performed in 33 patients with＂cool or cold nodule＂within two weeks before operation.99TcmO4-and99TcmN- NOET SPECT were performed every other day. The pathology results were colleted after operation. The characters of the nodules were defined by naked-eye and the semiquantitative measurements of T / N. Results All patients were divided into two groups based on the pathology. Sixteen patients were diagnosed malignancy（group 1,G1）,1 male and 15 female,aged 24-78 years,mean age（51. 81 ± 15. 34）years,including 5 cases of papillary carcinoma,9 cases of follicular carcinoma and 2 cases of medullary. Whereas seventeen patients were diagnosed with adenomas（group 2,G2）,2 male and 15 female,aged 23- 78 years,mean age（49.65 ±12. 24）years. Of 16 cases of malignancy,14 cases were filled with NOET,and 2 cases were partly filled. The score of NOET was 2 in 10 cases and 3 in 6 cases. The total score of 16 cases was 38. Of 17 cases of benign lesions,15 cases were unfilled with NOET. Two cases of benign lesions were filled in surrounding of nodules and blank of center. The value of T / N was 1. 57 ± 0. 38 for G1 and 1. 05 ± 0. 36 for G2（t = 16. 095,P 0. 001）. Conclusion99TcmN- NOET SPECT and semiquantitative index are of significance in differential diagnosis of thyroid nodule.

关 键 词：99TcmN-NOET 甲状腺癌 靶非靶比值 

分 类 号：R445[医药卫生—影像医学与核医学]