甲状旁腺激素水平对维持性血液透析患者生存质量的影响  

Effects of parathyroid hormone on quality of life in hemodialysis patients

作　　者：刘东[1] 高卓[1] 魏学明[2] 李新伦[1] 胡瑞海[1] 李红霞[1] 缪静[1] 伦立德[1] 

机构地区：[1]空军总医院肾病科,北京100142 [2]空军总医院普通外科

出　　处：《山西医科大学学报》2014年第5期384-388,共5页Journal of Shanxi Medical University

基　　金：北京首都临床特色应用研究基金资助项目(Z111107058811085)

摘　　要：目的观察甲状旁腺激素水平对尿毒症维持性血液透析患者生存质量的影响。方法选取88例尿毒症维持性血液透析治疗患者,根据全段甲状旁腺激素(iPTH)水平,分为iPTH>800 pg/ml组31例、iPTH 300-800 pg/ml组27例、iPTH150-299 pg/ml组30例,采用肾脏病生存质量KDQOL-SFTM量表进行问卷调查,根据Hays等提供的计分方法对结果进行评分。结果 iPTH>800 pg/ml组和iPTH 300-800 pg/ml组在肾病及透析相关生存质量总体健康评估(OHR)、症状与不适(SPL)、肾病对生活的影响(EKD)、认知功能(CF)、睡眠、SF-36、躯体健康(PF)、躯体角色功能(RP)、躯体疼痛(BP)、精力(VT)方面得分均低于iPTH150-299 pg/ml组(P<0.05或P<0.01)。iPTH>800 pg/ml组在躯体健康(PF)、躯体角色功能(RP)、总体健康(GH)方面得分低于iPTH 300-800 pg/ml组(P<0.05或P<0.01)。结论随着甲状旁腺激素水平的增高,继发甲状旁腺功能亢进的尿毒症维持性血液透析患者的生存质量下降。Objective To explore the effects of parathyroid hormone（ PTH） on health-related quality of life in uremic maintenance hemodialysis patients. Methods Eighty-eight uremic patients treated with hemodialysis were divided into three groups according to iPTH level：iPTH 〉 800 pg / ml group（n = 31）,iPTH 300- 800 pg / ml group（n = 27）,iPTH 150- 299 pg / ml group（n = 30）. Healthrelated quality of life（ HRQOL） was estimated with the KDQOL-SFTMquestionnaire and score methods provided by Hays. Results The scores in iPTH 800 pg / ml and iPTH 300- 800 pg / ml groups were lower on the overall health rating（OHR）,symptom / problem list（SPL）,effects of kidney disease（EKD）,cognitive function（CF）,sleep,SF- 36,physical function（PF）,role-physical（RP）,body pain（BP）,vitality（VT）than those in iPTH150-299 pg/ml group（P〈 0.01 or P〈 0.05）. The scores were lower in iPTH 〉800 pg/ml group than in iPTH 300- 800 pg / ml group on PF,RP,and general health（GH）（P 0. 01 or P 〈 0. 05）. Conclusion With the increase of parathyroid hormone,the quality of life decrease in uremic maintenance hemodialysis patients with secondary hyperparathyroidism.

关 键 词：血液透析 甲状旁腺激素 生存质量 

分 类 号：R581.1[医药卫生—内分泌]