斑块状银屑病皮损部位末梢血和肘正中静脉血中相关炎症因子含量的检测  

Lesion Serum and Vein Serum Contents of Inflammatory Factors in Patients with Plaque Psoriasis

作　　者：宋坪[1] 王晓旭[1] 李景利[2] 方素萍[1] 王永炎[3] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029 [3]中国中医科学院中医临床基础研究所,北京100700

出　　处：《中国中西医结合皮肤性病学杂志》2014年第2期75-77,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(30973758)

摘　　要：目的检测参与银屑病发病的相关炎症因子在皮损部位末梢血(以下简称皮损血)及肘正中静脉血(以下简称静脉血)中的含量情况。方法 34例斑块状银屑病患者,分别采集皮损血和静脉血,用双抗体夹心酶联免疫吸附法(ELISA法)分别检测并比较肿瘤坏死因子(TNF-α)、白细胞介素-8(IL-8)、P物质(SP)、银屑病p27抗原(Pso p27)在皮损血和静脉血中的含量。结果皮损血中TNF-α、IL-8、Pso p27的含量明显高于静脉血中的含量,差异有统计学意义(P<0.05);而皮损血中SP的含量低于静脉血中SP的含量,差异有统计学意义(P=0.002)。结论部分炎症因子在斑块状银屑病患者皮损血中的含量高于其在静脉血中的含量,提示炎症因子在皮损部位浓集可能是银屑病发病的重要因素。Objective To measure the inflammatory factors in lesion serum and vein serum collected from patients with plaque psoriasis.Methods The lesion serum and vein serum from 34 patients were collected.The contents of tumor necrosis factor （TNF-α）,interleukin-8（IL-8）,substance P （SP）,psoriasis-associated antigen p27（Pso p27） in lesion serum and vein serum were measured by enzyme-linked immunosorbent assay（ELISA）.Then compared the contents of inflammatory factors in lesion serum with them in vein serum,Results The contents of TNF-α,IL-8,Pso p27 in lesion serum were obviously higher than those in vein serum （P＜0.05）,but the content of SP in lesion serum was obviously lower than that in vein serum （P=0.002）.Conclusion The contents of some inflammatory factors are higher in lesion serum than those in vein serum.It is suggests that the high contents of inflammatory factors in lesion serum may be an important factor in the pathogenesis of psoriasis.

关 键 词：斑块状银屑病 皮损部位末梢血 肘正中静脉血 白细胞介素-8 银屑病p27抗原 P物质 肿瘤坏死因子-α 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]