辛伐他汀与二甲双胍联合应用对颈动脉粥样硬化斑块形态学的影响  

The effect of simvastatin and metformin in treating carotid artery atherosclerotic plaque

作　　者：李新爱 田庆新[2] 高树英 殷镜海[2] 

机构地区：[1]济南护理职业学院,山东济南250102 [2]山东中医药大学附属医院,山东济南250011 [3]山东莒县人民医院,山东莒县276500

出　　处：《中国中西医结合影像学杂志》2014年第2期150-152,共3页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：山东省自然科学基金(Y2007C159)

摘　　要：目的:探讨辛伐他汀与二甲双胍联合应用对糖尿病并发动脉粥样硬化(atherosclerosis,AS)患者颈部AS斑块的影响及其作用。方法:选取糖尿病并发AS患者120例,将其随机分为辛伐他汀组、二甲双胍组、联合治疗组(辛伐他汀和二甲双胍)、空白对照组,疗程6个月。分别于治疗前后行颈动脉超声,观察治疗前后颈动脉内中膜厚度(intima-media thickness,IMT)变化,计算斑块面积、斑块Crouse积分。结果:治疗6个月后,各药物治疗组的IMT、斑块面积及Crouse积分较治疗前明显减小(P<0.05或<0.01),联合治疗组治疗后IMT、斑块面积及Crouse积分显著小于辛伐他汀组、二甲双胍组(P<0.05)。结论:辛伐他汀联合二甲双胍具有抗AS的作用,能明显减轻颈部AS病变程度,疗效优于单独使用辛伐他汀或二甲双胍。Objective：To evaluate the effect of simvastatin and metformin in treating carotid artery atherosclerotic plaque in dia-betic patients with atherosclerosis .Methods ：120 diabetic patients with atherosclerosis were divided into 4 groups randomly ：sim-vastatin group ,metformin group ,combination group （simvastatin and metformin） ,control group .The course of treatment was six month .To observe changes of carotid intima-media thickness （IM T ） ,IM T area ,plaque integral of carotid artery with high resolving power ultrasound .Results：After 6 month of treatment ,each group could decrease IMT ,plaque area ,plaque integral significantly（P〈0 .05 or P〈0 .01） .The combination group showed more significant efficacy compared with simvastatin group and metformin group（P〈0 .05） .Conclusion：Simvastatin combined with metformin can significantly reduce atherosclerotic le-sions in the carotid artery and has the effect of anti-atherosclerosis ,which are superior to the principle of simvastatin and met-formin .

关 键 词：动脉粥样硬化 糖尿病 二甲双胍 超声检查 

分 类 号：R543.5[医药卫生—心血管疾病]