托烷司琼与格拉司琼联合甲氧氯普胺预防化疗所致恶心、呕吐的成本-效益分析  

Analysis of the effectiveness and cost: tropisetron with granisetron plus metoclopramide preventing chemotherapy-induced nausea and vomiting

作　　者：侯敏[1] 赵妍丽[1] 李秋梅[1] 谭榜宪[1] 

机构地区：[1]川北医学院附属医院肿瘤科,四川南充637000

出　　处：《川北医学院学报》2014年第2期177-180,共4页Journal of North Sichuan Medical College

基　　金：四川省卫生厅科研项目(100149)

摘　　要：目的:评价托烷司琼与格拉司琼联合甲氧氯普胺预防化疗所致恶心、呕吐的治疗效果及成本-效益比。方法:收集2012年1月至2012年11月经病理学和细胞学证实的恶性肿瘤(食管癌、鼻咽癌)80例,随机分为A组40例、B组40例,分别应用托烷司琼及格拉司琼联合甲氧鲁普胺预防化疗所致恶心、呕吐,观察止吐效果并进行成本-效益分析。结果:A、B两组止吐有效率分别为92.5%和87.5%(P>0.05);成本/效益比分别为2.06和0.70。结论:托烷司琼与格拉司琼联合甲氧氯普胺预防化疗所致恶心、呕吐的疗效相似,但后者成本-效益比好。Objective：To evaluate the effectiveness and cost of tropisetron plus metoclopramide and granisetron plus metoclopramide to prevent chemotherapy-induced nausea and vomiting. Methods ： From January 2012 to November 2012,80 patients with nasopharynge al carcinoma and esophageal carcinoma were randomly divided into two groups：A and B,which are proved by pathology and cytology. The patients in the A or B group respectively receive tropisetron or granisetron and metoclopramide to prevent chemotherapy-induced nausea and vomiting. The result of vomit-stopping was observed and the effectiveness and cost were analyzed. Results ： The effective rate of group A and B was 92.5 % and 87.5% （ P 〉 0. 05 ） ; proportionality of effectiveness and cost was 2. 06 and 0. 70. Conclusion ： The effects of tropisetron joint metoclopramide and granisetron joint metoclopramide used to prevent chemotherapy-induced nausea and vomi ting resembled;and the cost of receiving granisetron plus metoclopramide can be reduced.

关 键 词：托烷司琼 格拉司琼 甲氧氯普胺 成本-效益分析 恶心 呕吐 

分 类 号：R969[医药卫生—药理学]