辅助生殖技术受孕单绒毛膜双羊膜囊双胎妊娠特殊并发症的分析  

Specific Complications of Monochorionic Diamniotic Twin Pregnancy Conceived by Assisted Reproductive Technology

作　　者：卫星[1] 孙路明[1] 邵长香 邹刚[1] 周奋翮[1] 杨颖俊[1] 

机构地区：[1]同济大学附属上海市第一妇婴保健院,上海200040

出　　处：《生殖与避孕》2014年第5期360-362,373,共4页Reproduction and Contraception

摘　　要：目的:探讨辅助生殖技术(ART)受孕单绒毛膜双羊膜囊(MCDA)双胎妊娠特殊并发症及胎儿的结构异常发生情况。方法:回顾性分析2010.06~2013.09期间由ART受孕在本院产检及分娩的44例MCDA双胎妊娠患者的临床资料(ART受孕组),分析MCDA双胎的特殊并发症及胎儿结构异常,并与同期的自然受孕的MCDA双胎组(自然受孕组,n=360)进行比较。结果:ART受孕组母体平均年龄及BMI均较自然受孕组明显增高(P<0.01),组间初产妇比例无统计学差异(P>0.05)。MCDA双胎妊娠中双胎输血综合征(TTTS)81例,占20.0%;选择性宫内生长受限(sIUGR)47例,占11.6%,双胎反向动脉灌注序列(TRAPS)10例,占2.5%;胎儿结构异常25例,占6.2%。ART受孕组与自然受孕组MCDA双胎特殊并发症及胎儿结构异常的发生风险无统计学差异(P>0.05)。结论:ART受孕对MCDA双胎妊娠特殊并发症及胎儿结构异常的发生无明显影响。Objective： To explore the specific complications and fetal structural abnormalities of monochorionic diamniotic twin pregnancy conceived by assisted reproductive technology （ART）. Methods： Retrospective analysis of 44 cases of monochorionic diamniotic twin pregnancies admitted with ART in our hospital between June 2010 to September 2013 was performed for this study. The MCDA twin specific complications and fetal structural abnormalities were analyzed and compared with conceived spontaneously （SC group, n=360） MCDA twin pregnancies. Results： The mean age and average body mass index （BMI） of pregnent women were found to be higher in ART group than those in SC group （P〈0.01）. The proportions of primipa- rous women were similar （/~〉0.05）. In monochofionic twin pregnancies, there were 81 cases with twin to twin transfusion syndrome （TTTS, 20.0%）, 47 with selective intrauterine fetal growth restriction （sIUGR, 11.6%）, 10 with twin reversed arterial perfusion sequence （TRAPS, 2.5%） and 25 with fetal structural abnormalities （6.2%）. The incidences of specific complications and fetal structural abnormalities showed no significant difference between ART group and SC group （/9〉0.05）. Conclusion： ART conception does not increase the risk of specific complications and fetal structural abnormalities in MCDA twin pregnancy.

关 键 词：辅助生殖技术(ART) 单绒毛膜双羊膜囊(MCDA)双胎 胎儿结构异常 双胎输血综合征(TTTS) 选择性宫内生长受^(sIUGR) 双胎反向动脉灌注序列(TRAPS) 

分 类 号：R714.8[医药卫生—妇产科学]