海洛因依赖者大脑自发活动强度变化的低频振幅fMRI研究  

Amplitude of low-frequency oscillations in heroin dependent individuals：a resting state fMRI study

作　　者：王丽娜[1] 张东升[1] 朱佳[1] 李强[1] 李玮[1] 王涵月[1] 陈佳杰[1] 李永斌[1] 严雪娇[1] 王亚蓉[1] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《实用放射学杂志》2014年第5期721-724,共4页Journal of Practical Radiology

基　　金：国家自然科学基金项目（81071142,81071143,81201081）。

摘　　要：目的：探讨海洛因依赖者与健康对照者大脑神经元自发活动的差异。方法应用3.0T 磁共振扫描仪，采集20例男性海洛因依赖者（海洛因组）与15例人口学匹配的健康志愿者（对照组）静息态 fMRI 数据，比较2组间低频振幅的差异。结果与对照组相比，海洛因组喙侧扣带回脑区（双侧前扣带回、内侧前额叶）低频振幅活动明显减弱，未发现低频振幅增强的区域。结论海洛因依赖者静息态下喙侧扣带回区域功能异常，这可能导致海洛因依赖者认知功能损伤，且在成瘾者复吸想法转变为行为的过程中具有重要作用。Objective To explore the changes of cerebral local neuronal spontaneous activity between heroin dependent individuals and normal controls.Methods 3.0 T MRI were used for data acquisition,fMRI data were acquired during resting state from 20 male heroin dependent individuals（HD）and 1 5 matched normal controls（NC）,and then the difference of amplitude of low frequency fluctuation （ALFF）between groups were analysised.Results Compared with NC,ALFF in rostral cingulated zone（bilateral anteri-or cingulate cortex ,medial prefrontal cortex ）was significantly reduced in HD.Conclusion Dysfunction of resting state in RCZ were observed in HD,which may result in cognitive impairment and plays an important role in the transitions from ideas into behav-ior of relapse in addiction.

关 键 词：海洛因 静息态 低频振幅 功能磁共振成像 

分 类 号：R966[医药卫生—药理学] R322.81[医药卫生—药学]