出生后早期营养过度导致成年期胰岛素抵抗  

Early postnatal overnutrition results in insulin resistance in adulthood

作　　者：贝斐[1] 蔡威[1] 

机构地区：[1]上海交通大学医学院附属新华医院临床营养科、上海市小儿消化与营养重点实验室,200092

出　　处：《中华内分泌代谢杂志》2014年第5期368-372,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：出生后早期是生长发育的关键期，如营养过度会导致成年期持续性和永久性的体重过重／肥胖和胰岛素抵抗等代谢综合征表现，胰岛素作用的重要靶器官如肝脏、脂肪组织、骨骼肌和中枢神经系统均可出现胰岛素抵抗。涉及的主要机制包括胰岛素信号通路异常、游离脂肪酸和部分脂肪因子分泌增加、氧化应激、摄食／厌食神经调节失衡、下丘脑一垂体一肾上腺轴／糖皮质激素调节失常以及表观遗传的作用等。建议出生后早期避免营养过度，以减少成年期胰岛素抵抗发生的危险。Overnutrition during the early postnatal life, a critical time window for growth and development, may induce metabolic syndrome later in life, including overweight/obesity and insulin resistance. The important target organs of insulin, such as liver, adipose tissue, skeletal muscle, and central nervous systems show insulin resistance. The involved mechanisms include abnormality of insulin signal pathway, increment of free fatty acid and some adipocytokines, oxidative stress, maladjustment of orexigenic and anorexigenic neuron, modifications of the hypothalamic-pituitary-adrenal glucocorticoid axis as well as epigenetic, etc. Hence, overnutrition should be avoided during the early postnatal life, so as to decrease the risk of developing long-term insulin resistance.

关 键 词：出生后 营养过度 胰岛素抵抗 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌]