安徽地区肝内胆管结石危险因素的流行病学研究  

A case-control study on risk factors of hepatolithiasis in anhui district

作　　者：李袤 刘付宝[1] 耿小平[1] 赵红川[1] 赵义军[1] 王国斌[1] 张志功[1] 黄帆[1] 谢坤[1] 方德宝[1] 

机构地区：[1]安徽医科大学第一附属医院器官移植中心,合肥市230022

出　　处：《中华全科医学》2014年第7期1023-1025,共3页Chinese Journal of General Practice

基　　金：安徽省科技厅重点科研资助项目(12070403071)

摘　　要：目的采用回顾性病例对照研究的方法,调查、收集和分析安徽地区肝内胆管结石患者的生活资料,分析可能导致该病的危险因素。方法病例组和对照组样本均选自安徽医科大学第一附属医院2012年1月—2013年6月的住院病例。病例组样本均为经手术证实的肝内胆管结石患者,对照组采用1∶1配对方法,选择经腹部影像学检查排除胆道系统结石的患者。数据收集采用统一的流行病学问卷调查表,收集2组样本的一般情况、生活环境和体格检查等资料,并录入SPSS 13.0软件中。首先对各变量进行单因素Logistic回归分析,然后对可能受到混杂因素干扰的变量进行多因素Logistic回归分析,最后将筛选出的因素拟合主效应模型并分别计算人群特异危险度百分比(PAR%)。结果肝内胆管结石的危险因素包括低身高体重指数(P<0.001,OR=17.295,PAR%64.19%)、低油脂饮食(P<0.001,OR=7.583,PAR%54.23%)、井水水源(P=0.008,OR=7.806,PAR%55.06%)、胆道蛔虫病史(P=0.001,OR=7.537,PAR%24.63%)和胆道炎症史(P<0.001,OR=12.491,PAR%25.64%)。结论安徽地区肝内胆管结石的危险因素包括低身高体重指数、低油脂摄入、井水水源、胆道蛔虫病史和胆道炎症史。Objective Through the collections and analysis of the information of patients with hepatolithiasis,this research used a retrospective case-control study and tried to reveal the risk factors of hepatolithiasis in Anhui District. Methods All the cases in the experimental group and control group were chosen from inpatients of the 1st Affiliated Hospital of Anhui Medical University from January 1st,2012 to June 30th,2013. In order to diagnose and treat the hepatolithiasis,every case in the experimental group had undergone an operation,while the ones in the control group receive abdominal imagining examination to exclude the possibility of biliary gallstones. The questionnaire had unified criteria which collected and analyzed the two groups＇ information about their general appearance,living conditions,physical examinations,etc. Hence, we performed a database by SPSS Statistics 13. 0 and used Logistic regression analysis to test every variable respectively. Furthermore,all the variables were categorized into small groups according to their features. Then,confounding variables were eliminated and significant variables were introduced into the main effect pattern. Besides,every significant variable＇ s population attributable risk percent（ PAR%） was calculated respectively. Results The risk factors of hepatolithiasis included low Body Mass Index（ P〈0. 001,OR = 17. 295,PAR% = 64. 19%）,low oil and fat diet（ P〈0. 001,OR = 7. 583, PAR% = 54. 23%）,drinking well water（ P = 0. 008,OR = 7. 806,PAR% = 55. 06%）,medical history of biliary ascariasis（ P = 0. 001,OR = 7. 537,PAR% = 24. 63%） and medical history of cholangitis（ P〈0. 001,OR = 12. 491,PAR% = 25. 64%）. Conclusion The risk factors of hepatolithiasis were low Body Mass Index,low oil and fat diet,drinking well water,medical history of biliary ascariasis and medical history of cholangitis.

关 键 词：肝内胆管结石 危险因素 病例对照研究 

分 类 号：R657.42[医药卫生—外科学]