β-受体阻滞剂对高血压患者房颤发生的预防作用  

Prevention of atrial fibrillation about beta blockers in patients with hypertension

作　　者：郜黎伟[1] 邱林林[1] 赵宏[1] 

机构地区：[1]江苏省丹阳市人民医院,江苏丹阳212300

出　　处：《吉林医学》2014年第14期3021-3022,共2页Jilin Medical Journal

摘　　要：目的:研究高血压患者出现心房颤动(AF)前预防使用β-受体阻滞剂的作用及意义。方法:对高血压患者治疗组128例和对照组128例进行24小时动态心电图及实验室检查,并对结果进行分析。结果:AF发生例数两组比较差异无统计学意义(P>0.05),治疗组血清PⅠCP、PCⅢ及TGF-β1水平明显低于对照组(P<0.05)。结论:β-受体阻滞剂通过阻断自主神经以逆转心肌纤维化减少AF发生,实现对高血压患者房颤发生的预防作用。Objective To evaluate the role of beta blockers and significance in prevention of atrial fibrillation（ AF） in patients with hypertension. Methods The levels of PⅠCP and procollagen type Ⅲ（ PCⅢ） and Transforming growth factor beta 1（ TGF-β1） were measured by enzyme linked immunosorbent assay（ ELISA） in 128 hypertension patients in the treatment group and 128 controls,24 hours dynamic electrocardiogram were measured also. Results There are no significant difference abort AF cases occurred in two groups（ P〉0. 05）,serum P Ⅰ CP and PC Ⅲ and TGF-beta 1 level is significantly lower in treatment group than in control group（ P〈0. 05）. Conclusion Beta blockers reduced AF by blocking autonomic nerve to reverse myocardial fibrosis,and impact in the prevention of AF in patients with hypertension.

关 键 词：心房颤动 Β-受体阻滞剂 心肌纤维化 

分 类 号：R544.1[医药卫生—心血管疾病] R541.7[医药卫生—内科学]