金属纳米粒子在手性拆分及手性识别领域中的应用  

Applications of Metal Nanoparticles in Chiral Separation and Chiral Recognition

作　　者：李世滋 丁国生[1,2] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]天津大学分析测试中心,天津300072

出　　处：《分析测试学报》2014年第5期615-620,共6页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(21005054;21275081)

摘　　要：手性是自然界的本质属性,开发新的快速、高效、灵敏的手性分离分析方法对于对映体的立体选择性合成、手性药物的药理研究、对映体的纯度分析以及环境监测均具有重要意义。金属纳米粒子具有比表面积大、稳定性好和表面易修饰等优点,因而可作为理想的载体用于手性色谱领域;由于导带电子的集体震荡而产生的特殊的表面等离子体共振、荧光和催化性能等,使得金属纳米粒子在光学、电化学等手性传感器方面的应用和理论研究也不断深入。该文对近年来不同类型金属纳米粒子(金纳米粒子、银纳米粒子、量子点、磁性纳米粒子等)在手性分离和手性识别领域的应用现状进行了综述,并对该领域今后的发展进行了展望。Chirality is the intrinsic attribute of the nature. It is of great importance to develop new,rapid, efficient and sensitive chiral separation and analysis methods for enantioselective synthesis,ehiral drugs pharmacological research, enantiomeric purity analysis and environmental monitoring.Metal nanoparticles can be used as ideal supporting materials for chiral chromatography due to theirlarge surface area, good stability and easy post-functionalization. Furthermore, some kinds of metalnanoparticles own unique properties for surface plasmon resonance resulting from the collective oscilla-tions of conduction band electrons, fluorescence and catalysis, so the practical applications and theo-retical studies of metal nanoparticles in the area of chiral sensors are going deep. In this review, therecent applications of different metal nanoparticles （gold nanoparticles, silver nanoparticles, quan-tum dots, magnetic nanoparticles, etc. ） in chiral separation and recognition are reviewed, and thefuture developments in this field are also prospected.

关 键 词：金属纳米粒子 手性识别 手性拆分 综述 

分 类 号：O657.7[理学—分析化学]