脓毒症患者血清白介素23和白介素17水平的变化及其临床意义  

Significance of Serum Interleukin- 23 and Interleukin-17 on Patients with Sepsis

作　　者：苏华[1] 

机构地区：[1]南华大学附属第一医院重症医学科,湖南省衡阳市421001

出　　处：《实用心脑肺血管病杂志》2014年第6期38-39,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨脓毒症患者血清白介素23(IL-23)、白介素17(IL-17)水平的变化及其临床意义。方法选取2012年1月—2013年6月我院收治的脓毒症患者50例作为脓毒症组,根据住院后第28天患者的生存状况将其分为生存组29例和死亡组21例,另选取同期我院健康体检者50例作为对照组。采用ELISA法测定所有受试者血清IL-23、IL-17水平,并在脓毒症患者进入ICU 24 h内对其进行急性生理学和慢性健康状况评分系统Ⅱ(APACHEⅡ)评分。结果脓毒症组血清IL-23、IL-17水平均高于对照组(P<0.01)。死亡组APACHEⅡ评分及血清IL-23、IL-17水平均高于生存组(P<0.05)。直线相关分析结果表明,脓毒症患者血清IL-23、IL-17水平与APACHEⅡ评分均呈正相关(r值分别为0.73、0.76)。结论脓毒症患者血清IL-23、IL-17水平与疾病危重程度密切相关,可以作为反映病情变化的标志物。Objective To explore the clinical significance of serum interleukin-23（ IL-23） and interleukin- 17（ IL-17） on patients with sepsis. Methods 50 patients with sepsis admitted to our hospital from January 2012 to June 2013 were selected as sepsis group,according to the living condition of the 28 days of hospitalization patients were divided into subgroups survival（ 29 cases） and death（ 21 cases）,50 cases of healthy people were selected as control group at the same period. The serum IL- 23 and IL- 17 were detected by ELISA. The APACHE Ⅱ score were evaluated in sepsis patients within 24 h after entering ICU. Results Serum IL- 23 and IL- 17 in sepsis group were higher than those of control group（ P〈0. 01）. The APACHE Ⅱ scores and serum IL- 23 and IL- 17 in death subgroup were higher that those of survival group（ P〈0. 05）. Serum IL- 23 and IL- 17 in sepsis patients were positively correlated with APACHE Ⅱ scores（ r = 0. 73,0. 76）. Conclusion Serum IL- 23 and IL- 17 in sepsis patients are closely related to the degree of critical illness,and also can be used as markers to reflect the changes.

关 键 词：脓毒症 白介素23 白介素17 

分 类 号：R631[医药卫生—外科学]