有氧运动对乳腺癌患者癌因性疲乏疗效的Meta分析  

Effects of Aerobic Exercise on Cancer-related Fatigue in Breast Cancer Patients Receiving Chemotherapy: A Meta-analysis

作　　者：邹凌云[1] 杨柳[1] 何晓玲[1] 宋祎[1] 徐锦江[2] 

机构地区：[1]辽宁医学院,辽宁省锦州市121000 [2]辽宁医学院附属第一医院

出　　处：《中国全科医学》2014年第13期1524-1528,1537,共6页Chinese General Practice

基　　金：辽宁省科技厅课题(2013225305)

摘　　要：目的研究表明有氧运动可缓解乳腺癌患者因化疗引起的癌因性疲乏(CRF),但仍有部分研究存在争议性结论,本研究旨在探讨有氧运动对乳腺癌化疗患者CRF的干预疗效。方法计算机检索Pubmed、Embase、CISCOM、CINAHL、谷歌学术、CBM和中国知网等中英文数据库。检索范围从建库至2013-09-01,采用STATA 12.0软件进行Meta分析,计算标准均方差(SMD)及其95%可信区间(95%CI)评价两者关联性。结果本研究共计纳入了12项病例对照研究共1 014例乳腺癌化疗患者,其中包括522例有氧运动患者(试验组)和492例对照患者(对照组)。Meta分析的结果表明:试验组的Piper疲乏量表(RPFS)评分低于对照组,差异有统计学意义〔SMD=-0.82,95%CI(-1.04,-0.60),P<0.001〕;然而,癌症治疗功能评估疲乏量表(FACIT-F)评分在两组间差异无统计学意义〔SMD=0.09,95%CI(-0.07,0.25),P=0.224〕。根据不同种族进行亚组分析发现,两组RPFS和FACIT-F评分在亚洲人群中差异有统计学意义〔RPFS:SMD=-1.08,95%CI(-1.35,-0.82),P<0.001;FACIT-F:SMD=1.20,95%CI(0.70,1.71),P<0.001〕,但是在欧美人群中差异无统计学意义(P>0.05)。结论有氧运动可以有效改善乳腺癌患者化疗引起的CRF,尤其在亚洲人群中表现更为明显。Objective Studies show that aerobic exercise may receive cancer-related fatigue of breast cancer patients undergoing chemotherapy,but some with controversial results. This meta-analysis is aimed to explore the intervention effects of aerobic exercise on CRF in breast cancer patients receiving chemotherapy. Methods A literature search of PubMed,Embase, CISCOM,CINAHL,Google Scholar,CNKI and CBM databases was conducted on articles published before September 1st, 2013. STATA 12. 0 software was used for the meta-analysis. Crude standardized mean difference（ SMD） and its 95% confidence interval（ CI） were calculated,and according to the results the association of the two was assessed. Results Twelve cases were brought into the comparative studies with a total of 1 014 breast cancer patients receiving chemotherapy,including 522 patients in the aerobic exercise group（ the intervention group） and 492 patients in the usual care group（ the control group）. The meta-analysis results revealed that the RPFS scores of breast cancer patients in the intervention group were significantly lower than those in the control group 〔SMD =-0. 82,95% CI（-1. 04,-0. 60）,P〈0. 001〕. However,there was no significant difference in FACIT-F scores between the intervention and control groups 〔SMD = 0. 09,95% CI（-0. 07,0. 25）,P = 0. 224〕. Subgroup analysis by ethnicity indicated that there were significant differences in RPFS and FACIT-F scores between the intervention and control groups among Asian populations 〔RPFS： SMD =-1. 08,95% CI（-1. 35,-0. 82）,P〈0. 001; FACIT-F： SMD = 1. 20,95% CI（ 0. 70,1. 71）,P〈0. 001〕,but no significance among Caucasian populations（ P〈0. 05）. Conclusion The current meta-analysis indicates that aerobic exercise may improve cancer-related fatigue in breast cancer patients receiving chemotherapy,especially among Asian populations.

关 键 词：有氧运动 癌因性疲乏 乳腺肿瘤 化疗 META分析 

分 类 号：R195.1[医药卫生—卫生统计学]