胃炎Ⅰ号颗粒治疗肝胃不和型消化性溃疡临床研究  

Disharmony of Gastritis and Peptic No.Ⅰ Clinical Study Particle Therapy

作　　者：魏晏[1] 魏明[2] 

机构地区：[1]河南中医学院第三附属医院,河南郑州450008 [2]河南中医学院第一附属医院,河南郑州450000

出　　处：《中医学报》2014年第5期735-737,共3页Acta Chinese Medicine

基　　金：国家科技部十一五科技支撑计划项目(编号:2007BAI20B094);河南省科技厅科技攻关项目(编号:112102310112)

摘　　要：目的:观察胃炎Ⅰ号颗粒治疗肝胃不和型消化性溃疡的临床疗效,为新药开发提供临床依据。方法:160例患者按就诊先后顺序用随机数字表法平均分为治疗组和对照组,每组各80例。对照组采用奥美拉唑治疗,合并HP感染者配合克拉霉素、甲硝唑。治疗组在对照组基础上加用胃炎Ⅰ号颗粒,每日1剂,早晚饭后温服。两组均以6周为1个疗程,疗程结束后统计疗效,3个月后随访统计复发率。治疗期间所有患者均忌酒戒烟,勿食辛辣刺激食物,少食生冷油腻,勿过饥过饱,保持心情舒畅。结果:①两组患者临床证候疗效比较:对照组80例,治愈14例,治愈率17.50%;有效率为81.25%。治疗组80例,治愈32例,治愈率40.00%;有效率92.50%。两组痊愈率比较,χ2=9.886,υ=1,P=0.002,治疗组优于对照组;两组有效率比较,χ2=4.440,υ=1,P=0.035,治疗组优于对照组。②两组患者胃镜下疗效比较:对照组80例,治愈17例,治愈率21.25%;有效率为65.00%。治疗组80例,治愈30例,治愈率37.50%;有效率82.50%。两组痊愈率比较,χ2=5.091,υ=1,P=0.024,治疗组优于对照组;两组有效率比较,χ2=6.328,υ=1,P=0.012,治疗组优于对照组。③两组患者HP感染疗效比较:对照组80例,HP感染61例,治愈45例,治愈率73.77%;治疗组80例,HP感染59例,治愈53例,治愈率89.83%;两组痊愈率比较,χ2=5.167,υ=1,P=0.023,治疗组优于对照组。④两组复发率比较:对照组80例,治愈14例,复发8例,复发率57.14%;治疗组80例,治愈32例,复发8例,复发率25.00%;两组复发率比较,χ2=4.436,υ=1,P=0.035,治疗组优于对照组。结论:胃炎Ⅰ号颗粒治疗肝胃不和型消化性溃疡疗效显著。Objective： To investigate the clinical efficacy of gastritis Ⅰ disharmony of particle number and type of peptic ulcer treatment, provide the basis for the clinical development of new drugs. Methods ： 160 patients were randomized according to treatment sequence with a random number table into the treatment group and the control group,80 cases in each group. The control group with omeprazole treatment,combined with HP infected clarithromycin, metronidazole. Treatment group were based on the use of gastritis No. Ⅰ particles a day, morning and evening meal, warm clothes. The two groups are 6 weeks of a course of treatment, after treatment efficacy statistics, three months after the recurrence rate of follow-up statistics. All patients avoid alcohol during treatment were quitting, Wu Shi spicy food, Eat cold greasy, not hunger satiety, to feel comfortable. Results：（1） two clinical syndromes comparison：the control group 80 cases, 14 cases were cured, the cure rate is 17.50% ;effective rate of 81.25 %. Treatment group 80 cases, 32 cases were cured, the cure rate is 40.00% ;efficiency 92.50%. Cure rate between the two groups,χ^2 = 9. 886,v = 1,P = 0. 002, the treatment group than the control group ; groups have more efficient ,χ^2 = 4. 440, v = 1, P = 0. 035, the treatment group than the control group. Two groups of patients under endoscopy （2） Comparison of efficacy： the control group 80 cases, 17 cases were cured, the cure rate is 21.25% ; effective rate of 65.00%. Treatment group 80 cases,30 cases were cured, the cure rate is 37.50% ; efficiency 82.50%. Cure rate between the two groups ,χ^2 = 5. 091 ,v = 1, P = 0. 024, the treatment group than the control group ; groups have more efficient,χ^2 = 6. 328, v = 1, P = 0. 012, the treatment group than the control group. （3） Comparison of efficacy of HP infection in two groups of patients：a control group of 80 patients,HP infection in 61 cases,45 cases were cured,the cure rate is 73.77% ;80 cases treated,HP infection in 59 cases,53 cases were

关 键 词：消化性溃疡 肝胃不和证 胃炎Ⅰ号颗粒 奥美拉唑 

分 类 号：R259.733[医药卫生—中西医结合]