自拟除湿解毒汤联合重组人干扰素α-2b阴道泡腾胶囊治疗宫颈高危型HPV感染的疗效观察  

Observation of the Curative Effect of Self-made Dehumidifying Detoxification Decoction Combined with Recombinant Human Interferon α-2b Vaginal Effervescent Capsules in Treatment of Cervical High Risk HPV Infection

作　　者：沈姚琴 王华[1] 邓娟[1] 

机构地区：[1]浙江中医药大学附属嘉兴市中医院,浙江嘉兴314001

出　　处：《中国现代应用药学》2014年第5期603-606,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省中医药科技计划项目(2013ZB132)

摘　　要：目的观察中药除湿解毒汤联合重组人干扰素α-2b阴道泡腾胶囊(辛复宁)治疗宫颈高危型HPV感染的疗效。方法将宫颈高危型HPV感染患者随机分3组,随访组50例,无药物干预;西药组65例,重组人干扰素α-2b阴道泡腾胶囊阴道给药,治疗3疗程;中西药组65例,重组人干扰素α-2b阴道泡腾胶囊治疗同时口服自拟除湿解毒汤3疗程。比较3组疗效。结果西药组与中西药组在宫颈病变、中医证候、HPV转阴方面的疗效均明显高于随访组,差异有统计学意义(P<0.01)。西药组与中西药组比较,宫颈病变治疗总有效率差异无统计学意义,但中西药组显效率(60.00%)高于西药组(41.54%),差异有统计学意义(P<0.05);中医证候总有效率比较2组差异无统计学意义,但中西药组显效率(69.23%)高于西药组(46.15%),差异有统计学意义(P<0.01);HPV转阴总有效率西药组67.69%,中西药组83.08%,差异有统计学意义(P<0.05)。结论宫颈高危型HPV感染药物干预有积极意义,中西药结合治疗在祛除HPV以及改善症状体征方面更具优势。OBJECTIVE To observe the effect of dehumidifying detoxification decoction combined with Recombinant Human Interferon α-2b Vaginal Effervescent capsules in the treatment of cervical high risk HPV infection. METHODS Cervical high risk HPV infection patients were randomly divided into three groups： 50 cases in follow-up group, non drug intervention; 65 cases in the western medicine group, Recombinant Human Interferon α-2b Vaginal Effervescent capsulestreatment for 3 courses; 65 cases in Chinese western medicine group, treated with Recombinant Human Interferon ct-2b Vaginal Effervescent capsules and oral self-made dehumidifying detoxification decoction for 3 courses. Observation of the effects of 3 groups. RESULTS Efficacy of the western medicine group and the Chinese western medicine group were significantly higher than follow-up group in cervical disease, TCM syndromes, HPV negative conversion, the difference was statistically significant（P〈0.01）. The comparison between the western medicine group and the Chinese western medicine group, there was no significant difference in the total efficiency of the treatment of cervical lesions, but the significant efficiency in Chinese western medicine group was 60.00%, higher than that of 41.54% in Western medicine group, the difference was statistically significant（P〈0.05）. There was no significant difference in the total efficiency of the treatment of TCM syndromes, but the significant efficiency in Chinese western medicine group was 69.23%, higher than that of 46.15 % in western medicine group, the difference was statistically significant（P〈0.01）. The total efficiency in HPV negative conversion was 67.69% in western medicine group and 83.08% in Chinese western medicine group, the difference was statistically significant（P〈0.05）. CONCLUSION Drug intervention of cervical high risk HPV infection has a positive meaning. It has the advantage in effect of HPV scavenging and improve the symptoms, physical signs in the Chinese medicine combined with west

关 键 词：宫颈高危型HPV感染 重组人干扰素Α-2B阴道泡腾胶囊 中药除湿解毒汤 

分 类 号：R969.4[医药卫生—药理学]