宫颈上皮内瘤变Ⅱ～Ⅲ级患者HPV感染的分型及特点  

THE HPV GENOTYPES DISTRIBUTION IN PATIENTS WITH CINⅡ～Ⅲ

作　　者：王焕妮 王慧儒[1] 胡鹏[1] 韩彬[1] 邱章灿 莫凌昭[1] 

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科二病区,南宁530021

出　　处：《广西医科大学学报》2014年第2期220-222,共3页Journal of Guangxi Medical University

基　　金：广西自然科学基金资助项目(No.2010GXNSFC0130022)

摘　　要：目的：探讨宫颈上皮内瘤变（CIN）Ⅱ～Ⅲ级患者人乳头状瘤病毒（HPV）感染的分型及特点.方法：采用凯普HPV核酸扩增分型检测试剂盒方法对131例CINⅡ～Ⅲ级患者行HPV感染及基因的分型检测.结果：CINⅡ～Ⅲ级患者HPV感染率为86.26％（113/131）.单一感染率72.57％（82/113）,多重感染率27.43％（31/113）.HPV16为最常见亚型（48.85％）,其余亚型依次为HPV 58（20.61％）、HPV 33（11.45％）、HPV 31（8.40％）、HPV 52（7.63％）.结论：CINⅡ～Ⅲ级患者HPV单一感染率高于多重感染率,HPV16型和HPV58型可能是CINⅡ～Ⅲ级患者HPV感染的主要型别.Objective：To investigate the HPV genotypes distribution in 131 patients with CIN Ⅱ ～ Ⅲ.Methods：The HPV GenoArray test was used for detecting HPV genotypes in 131 patients with CIN Ⅱ ～Ⅲ.Results：The HPV infectious rate was 86.26% （113/131） in patients with high grade cervical intraepithelial neoplasia.The prevalence of single infection was 72.57% （82/113）,and the multiple infections were 27.43% （31/113）.HPV16 was the most common type （48.85%）,followed by HPV58 （20.61%）,HPV33 （11.45%）,HPV31 （8.40%） and HPV52 （7.63%）.Conclusion：The prevalence of single infection was higher than multiple infections.HPV16 and HPV58 maybe the most commonly detected genotypes in patients with CIN Ⅱ ～ Ⅲ.

关 键 词：宫颈上皮内瘤变 人乳头瘤病毒 基因分型 

分 类 号：R71[医药卫生—妇产科学]