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作 者:王家玉[1] 田睿[2] 贾运涛[3] 郭锋[1] 刘玉祺[1] 张良珂[1]
机构地区:[1]重庆医科大学药学院,重庆400016 [2]重庆医科大学实验教学中心,重庆400016 [3]重庆医科大学附属儿童医院药剂科,重庆400010
出 处:《中国医院药学杂志》2014年第10期797-800,共4页Chinese Journal of Hospital Pharmacy
基 金:重庆市自然科学基金项目(编号:cstc2012jjA10021);高等学校博士学科点专项科研基金(编号:20125503120003);重庆市卫生局医学科研项目(编号:2013-2-060);重庆医科大学大学生科研与创新实验项目(编号:201244;201229;201217);重庆市教育委员会科学技术研究项目(编号:KJ110323);海扶之星学生科研基金项目(编号:XS201309)
摘 要:目的:制备法莫替丁胃漂浮缓释微丸,并进行体外评价。方法:选取Eudragit L100和Eudragit RLPO作为固体分散体载体材料,以溶剂法制备法莫替丁固体分散体,粉碎过筛后加入海藻酸钠溶液中,再将混悬液滴入氯化钙醋酸溶液中交联10 min,干燥,得法莫替丁固体分散体胃漂浮微丸。以人工胃液为介质,考察微丸的漂浮率和释放度。结果:胃漂浮微丸持续12 h有95%以上的漂浮率;法莫替丁固体分散体胃漂浮微丸体外释放在5 h达到72%~81%。结论:制备的法莫替丁固体分散体胃漂浮微丸可在人工胃液中持续漂浮并缓慢释放药物。OBJECTIVE To prepare famotidine gastric floating sustained-release beads and evaluate its in vitro release behaviors. METHODS The solid dispersion of famotidine was obtained by the method of solvent. Eudragit L100 and Eudragit RLPO were used as the carrier material. After being crushed and sieved, the solid dispersion of famotidine was added in the al- ginate solution. Then, the suspension was dropped into the calcium chlorine acetic acid solution and stirred for 10 min. After drying, the famotidine solid dispersion gastric floating beads were obtained and its in vitro properties in simulated gastric fluid were investigated. RESULTS More than 95% of the gastric floating beads were kept floating in 12 h. The cumulative release percentage was found to be 72%~81% in 5 h. CONCLUSION The famotidine solid dispersion gastric floating beads could be kept floating in simulated gastric fluid and delay famotidine release from the beads.
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