6-氯-7-氮杂吲哚合成工艺研究  

Study on the Synthesis of 6-Chloro-7-azaindole

作　　者：施海风 龙飞飞[1] 黄龙江[1] 

机构地区：[1]青岛科技大学化工学院,山东青岛266042

出　　处：《精细化工中间体》2014年第2期47-49,共3页Fine Chemical Intermediates

摘　　要：以7-氮杂吲哚为原料,经N-氧化,氯化和水解等3步反应,制备了6-氯-7-氮杂吲哚,并考察了反应物料配比、反应溶剂对收率的影响。总收率为62.2%。6-Chloro-7-azaindole was prepared in an overall yield of 62.2% from 7-azaindole via N-oxidation, chlorination and hydrolysis. The influence factors on the yield of the target product were investigated. The structure was characterized with IH NMR. This improved process can simplify the scale manipulation and reduce the cost.

关 键 词：6-氯-7-氮杂吲哚 氯化 合成工艺 

分 类 号：TQ251.34[化学工程—有机化工]