Ugi多组分反应一锅法合成3-异吲哚酮-1-甲酰胺衍生物  

One pot synthesis of 3-oxoisoindoline-1-carboxamide derivatives by Ugi multicomponent reaction

作　　者：邓兰青[1,2] 易雪静[1] 吴瑛[1] 徐中海[1] 

机构地区：[1]岳阳职业技术学院岳阳市中草药综合利用重点实验室,湖南岳阳414000 [2]中南大学化学化工学院,湖南长沙410083

出　　处：《应用化工》2014年第5期831-834,共4页Applied Chemical Industry

基　　金：湖南省教育厅基金资助项目(13C974)

摘　　要：采用Ugi多组分一锅法反应,以2-羧基苯甲醛、胺、异腈为原料,以甲醇和乙腈为混合溶剂,室温下简便高效地合成了8个3-异吲哚酮-1-甲酰胺衍生物,收率均在75%以上,其结构用1H NMR、13C NMR和高效液质联用(LC-MS)进行了确证。8 Final compounds were synthesized by one pot Ugi multicomponent reaction,starting from sim-ple and readily available inputs including 2-formylbenzoic acid,isocyanide,and amine in the presence of methanol and acetonitrile,in excellent yields at room temperature. The yield reached above 75% . The structures of terminational compounds were determined by 1 H NMR,13 C NMR and LC-MS techniques.

关 键 词：3-异吲哚酮-1-甲酰胺 合成 2-羧基苯甲醛 胺 异腈 

分 类 号：TQ251.3[化学工程—有机化工]