高功率激光电离飞行时间质谱技术  

The Technique of High Irradiance Laser Ionization Time-of-Flight Mass Spectrometry

作　　者：何妙洪 杭纬[1] 黄本立[1] 

机构地区：[1]厦门大学化学化工学院、谱学分析与仪器教育部重点实验室,福建厦门361005

出　　处：《质谱学报》2014年第3期193-202,共10页Journal of Chinese Mass Spectrometry Society

基　　金：国家自然科学基金(21027011);教育部创新团队基金(IRT13036)资助

摘　　要：对于传统的高功率激光质谱存在的关键问题,如离子动能分散、多价离子和多原子离子干扰、基体效应和分馏效应等,高功率激光电离飞行时间质谱(LI-TOF MS)通过仪器结构设计及实验条件的优化等可以很好地解决。目前,LI-TOF MS的应用包括地质和金属样品中元素的定性和无标样半定量分析、非金属元素的测定、元素表面成像分析和薄层的深度剖析、液体残渣分析、复杂生物材料中元素组成的确定,甚至对于有机金属化合物也可以同时获得分子、碎片和元素信息。本工作综述了LI-TOF MS技术的发展历程,分析了其在不同领域中的优势,并对其应用领域拓展的新方向和仪器的改进目标进行了展望。This article reviews the development and the applications of high irradiance laser ionization time-of-flight mass spectrometry（LI-TOF MS）. The critical problems in tradi- tional high irradiance laser mass spectrometry, such as the large kinetic energy distribution of ions, multiply charged ions, polyatomic ions, matrix effect as well as fractionation effect, have been successfully solved via the new design of instrumental structure as well as the optimization of the experiment conditions. Recent applications include qualitative and sem^quantitative analysis of geological and metal solids without standards, determination of nonmetallic elements, elemental imaging and depth profiling of coatings, solution residue analysis, elemental analysis of complicated biomaterial, and simultaneous acquisition of ele- mental, fragmental, and molecular information on organometallic compounds, which demonstrates the high irradiance laser ionization time-of-flight mass spectrometry as a versatile technique in analysis.

关 键 词：激光电离 飞行时间质谱 固体分析 

分 类 号：O657.63[理学—分析化学]