左旋氧氟沙星对苯妥英钠在家兔的药代动力学影响的研究  

Effect of Levofloxacin on Pharmacokinetics of Phenytoin Sodium in Rabbits

作　　者：黄林清[1] 杨志勇[1] 

机构地区：[1]第三军医大学新桥医院药剂科,重庆市400037

出　　处：《中国药房》2001年第2期83-84,共2页China Pharmacy

摘　　要：目的 :研究左旋氧氟沙星对苯妥英钠血药浓度及药代动力学参数的影响。方法 :应用紫外分光光度法测定家兔喂服左旋氧氟沙星前及10d后单剂量静脉注射苯妥英钠的经 -时血药浓度 ,以“3p87”药代动力学程序拟合药动学参数。结果 :苯妥英钠经 -时血药曲线符合二室开放模型 ,合用左旋氧氟沙星后 ,苯妥英钠血药浓度均有不同程度的降低 ,部分药代动力学参数也有明显的改变。结论AIM:To study the effect of levofloxacin(LVFX)on serum concentrations and pharmacokinetics of phenytoin sodium(PHT)in rabbits.METHODS:Using UV-spectrophotometry,the serum concentrations of PHT were determined in nine rabbits before oral feeding LVFS and after a single dose of PHT given iv 10 days later.The pharmacokinetic parameters were worked out with 3p87 program.RESULTS:The concentration-time curve of PHT was fit to open two-compartment model.After co-administration of LVFX,the serum concentrations of PHT were decreased to some extent and part of pharmacokinetic parameters obviously changed as well.CONCLUSION:Co-administration of PHT and LVFX will accelerate the metabolic process of PHT.

关 键 词：左旋氧氟沙星 苯妥英钠 药代动力学 抗癫痫药 

分 类 号：R971.6[医药卫生—药品]