bBMP-胶原-珊瑚复合人工骨修复股骨头骨缺损的生物力学研究  

A biomechanical study of bBMP-collagen-coral composited bone substitute for the treatment of canine bone defect of the femoral head

作　　者：徐小良[1] 王坤正[2] 杨增华[2] 牒军[2] 党晓谦[2] 阎宏伟[2] 李旭东[2] 张开放[2] 陈君长[2] 

机构地区：[1]上海第九人民医院骨科 [2]西安医科大学第二附属医院,陕西西安710004

出　　处：《中国骨伤》2001年第1期17-19,共3页China Journal of Orthopaedics and Traumatology

摘　　要：目的　研究用bBMP 胶原 珊瑚复合人工骨修复股骨头骨缺损的生物力学变化。方法　建立狗双侧股骨头内骨缺损模型 ,4周后分为 5组 :复合人工骨组、肌骨瓣组、单纯珊瑚组、对照组、正常组。植入后 16周行病理学检查及生物力学测定。结果　人工骨组的骨缺损消失或显著变小 ,与对照组相比有显著性差异。人工骨组软骨下骨的抗压强度及弹性模量较对照组及正常组低。结论　复合人工骨有较强的修复股骨头骨缺损的能力 ,但不能改善软骨下骨的生物力学性能。Objective [HT5”SS]To study the biomechanical changes of bBMP collagen coral composited bone substitute for the treatment of canine bone defect of the femoral head.[HT5”H]Methods [HT5”SS]Canine bone defect of bilateral femoral head was established.After 4 weeks,they were divided into 5 groups:Ⅰ.composited bone substitute group;Ⅱ.Muscle pedicle bone group;Ⅲ.simple coral group;Ⅳ.control group;Ⅴ.normal group.Pathological and biomechanical changes of femoral head were studied at 16 weeks after treatment.[HT5”H]Results [HT5”SS]Compared with control group,the bone defect of group I was much smaller.The maximum stress and modulus of elasticity of subchondral bone of group I were lower than that of group V and group Ⅳ.[HT5”H]Conclusion [HT5”SS]The composited bone substitute possesses a superior property for repairing bone defect of femoral head,but it is unable to improve the biomechanical property of subchondral bone of femoral head.

关 键 词：股骨头坏死 骨质再生 生物力学 人工植入物 

分 类 号：R683.420.5[医药卫生—骨科学] R318.08[医药卫生—外科学]