复元散对激素性股骨头坏死微循环影响的实验研究  

Experimental study of the effects of Fuyuansan on microcirculation of steroid-induced necrosis of femoral head in rabbits

作　　者：洪加源[1] 许书亮[2] 阮景绰[3] 

机构地区：[1]中国人民解放军第175医院,福建漳州363000 [2]福建中医学院骨伤研究所 [3]福建省中医药研究院微循环研究室

出　　处：《中国骨伤》2001年第1期27-28,共2页China Journal of Orthopaedics and Traumatology

基　　金：福建省自然科学基金!资助项目 (编号 950 39)

摘　　要：目的　探讨验方复元散对激素性股骨头坏死微循环的影响。方法　 40只成年雄性新西兰大白兔随机分为模型组 (15只 ) ,复元散组 (15只 )和对照组 (10只 )。模型组采用臀肌注射醋酸氢化泼尼松 (简称激素 )建立股骨头骨细胞坏死模型。复元散组按上法注射激素并每日灌服复元散。每隔 2周各组分别进行全血粘度、甘油三酯、血清总胆固醇及骨内压测定。结果　模型组全血粘度、甘油三酯、血清总胆固醇及骨内压均明显升高 ,而复元散组各项指标无明显升高 (P <0 0 1)。结论　复元散能够改善股骨头微循环 ,扭转股骨头缺血状态 ,抑制本病的发生发展。Objective[WT5”BZ] To study the effects of Fuyuansan(Chinese herbal medicine) on microcirculation of steroid induced necrosis of femoral head.[WT5”HZ]Methods[WT5”BZ] 40 male adult New Zealand rabbits were randomly divided into three groups:model group( n =15),Fuyuansan group( n =15) and control group( n =10).Hydroprednisone acetate was injected into the rabbits of the model group using intragluteal injection to produce necrosis models of bone cells of femoral head.The rabbits of Fuyuansan group were injected the same agent using the same methods as model group.Meanwhile,the animals of Fuyuansan group were given Fuyuansan daily.The whole blood viscosity,triglyceride,serum total cholesterol and intraosseous pressure of each group were determined every two weeks.[WT5”HZ]Results[WT5”BZ] The whole blood viscosity,triglyceride,serum total cholesterol and intraosseous pressure of model group remarkably increased,but those of Fuyuansan group increased lightly(P<0 01).[WT5”HZ]Conclusion[WT5”BZ] Fuyuansan can improve microcirculation of femoral head,change ischemia conditions and prevent the development of necrosis of femoral head.

关 键 词：股骨头坏死 中草药 微循环 中医药疗法 

分 类 号：R274.918[医药卫生—中西医结合]