几种新癫痫药分别联合丙戊酸钠治疗难治性癫痫的对比  

Effect comparison of several new epilepsy drugs respectively combined with valproate contrast in the treatment of intractable epilepsy

作　　者：邓白荔 周舍典[1] 何清华[1] 陈逢俭[2] 

机构地区：[1]湛江中心人民医院药学部,广东省524037 [2]湛江中心人民医院神经内科

出　　处：《中国现代药物应用》2014年第11期3-6,共4页Chinese Journal of Modern Drug Application

摘　　要：目的：探讨部分难治性癫痫（RE）在添加拉莫三嗪（LTG）或奥卡西平（OXC）或托吡酯（TPM）联合丙戊酸钠（VPA）治疗的临床疗效。方法累积收集2009年1月~2014年1月符合标准的212例难治性部分性癫痫患者，对照治疗3个月前癫痫发作频度，并对治疗2年结束后的疗效、不良反应（ADR）及安全性和脑电图进行自身分析对比。结果患者应用LTG或OXC或TPM联合VPA治疗RE 2年结束后，患者发作频率均比用药前明显减少，患者治疗结束后的总有效率分别为89%、88.5%、78.1%， ADR的发生率分别为9.6%、19.2%、21.9%，脑电图总的好转率分别为89.9%、78.5%、76.9%。结论 LTG或OXC或TPM联合VPA治疗RE患者的疗效确切，耐受性好，安全性高， ADR轻。Objective To explores clinical effect of valproate （VPA） therapy combined with lamotrigine （LTG） or oxcarbazepine （OXC） or topiramate （TPM） in the treatment of refractory epilepsy （RE）. Methods Cumulative collection 212 standard patients with refractory partial epilepsy patients from 2009 to 2014, the control treatment three months ago seizure frequency, and 2 years after the end of therapy, the adverse reaction （ADR） and the safety and brain electrical diagram own analysis and comparison. Results Application of lamotrigine and oxcarbazepine or patients topiramate combined with sodium valproate in treatment of refractory epilepsy after 2 years, patients with seizure frequency than before treatment was significantly reduced in patients after treatment, the total effective rate was 89%and 88.5%and 78.1%;the incidence of ADR was 9.6%, 19.2%, 21.9%;EEG overall improvement rate was. 89.9%, 78.5%, 76.9%.Conclusion Effect of lamotrigine or oxcarbazepine or topiramate combined with sodium valproate in the treatment of intractable epilepsy patients exactly, good tolerance, high safety, ADR light.

关 键 词：难治性癫痫 拉莫三嗪 奥卡西平 托吡酯 丙戊酸钠 

分 类 号：R742.1[医药卫生—神经病学与精神病学]