腮腺炎疫苗分别与甲肝、白破、风疹疫苗联合免疫的效果观察  

IMMUNOLOGIC EFFECTS OF COMBINED IMMUNISING OF MUMPS AND HAPATITIS A、DT、RUBELLA VACCINES RESPECTIVELY.

作　　者：徐福根[1] 陈康凯[1] 黄诚孝[1] 许二萍[1] 黄利明[1] 祝水芬[1] 杨洛贤[1] 姚怀芳[1] 孟冬梅[1] 闻洪根[1] 

机构地区：[1]杭州市疾病预防控制中心,杭州310006

出　　处：《现代预防医学》2001年第1期19-21,共3页Modern Preventive Medicine

摘　　要：目的 :观察腮腺炎疫苗分别与甲肝、白破、风疹疫苗同时接种的临床反应和免疫效果。方法 :设两种疫苗同时接种组和单苗接种组 ,比较其副反应和血清抗体水平。结果 :各接种组临床反应都轻微 ,两苗同时接种组与相应的单苗接种组免前免后同种抗体阳性率或保护率和 GMT,以及免后抗体阳转率 ,其差异均无显著意义 (均 P>0 .0 5 )。结论 :腮腺炎疫苗与甲肝、白破、风疹减毒活疫苗之一同时接种未发现加重反应和相互干扰免疫应答 ,可以同时接种。Objective:To observe clinical reactions and immune responses of combined vaccinations of mumps and hepatitis A,rubella vaccine,diphtheria tetanus toxoids respectively.Methods:In every observation,children were simultaneously or respectively inoculated with 2 kinds of vaccines,adverse reaction events and antibody levels of them were compared.Rusults:The adverse reactions caused by concurrent or separate immunization were mild.Comparison of prevaccination antibody positive or protec tive rates and GMTs and post vaccination antibody positive conversion rates and GMTs in the simultaneous and respective inoculation groups showed no statistical differences(All P> 0 05).Conclusions:Concurrent vaccination of mumps and one of hepatitis A,DT and rubella vaccines did not interfere with antibody response and aggravate adverse reactions,they can be administered at the same time.

关 键 词：腮腺炎减毒活疫苗 甲肝减毒活疫苗 DT 风疹减毒活疫苗 

分 类 号：R512.1[医药卫生—内科学]