七氟烷吸入麻醉和丙泊酚全凭静脉麻醉对老年患者肝肾功能的影响  

Comparison of hepatic and renal function between inhalation anesthesia with sevoflurane and total intravenous anesthesia with propofol for geriatric patients

作　　者：李红宝[1] 何建国[2] 

机构地区：[1]宁波大学医学院附属医院麻醉科,浙江宁波315000 [2]宁波市第一医院麻醉科,浙江宁波315010

出　　处：《中国现代医生》2014年第15期71-74,共4页China Modern Doctor

基　　金：浙江省宁波市医学科技计划(2010A03)

摘　　要：目的比较七氟烷麻醉和丙泊酚麻醉对老年胃肠手术患者肝肾功能的影响。方法择期胃肠手术患者55例随机分为七氟烷麻醉组、丙泊酚麻醉组。监测术前和术后1 d、3 d患者血清天冬氨酸转移酶、丙氨酸转氨酶、血尿素氮和肌酸酐水平。结果与术前相比,两组患者AST术后1 d、3 d均升高,S组患者BUN在术后3d有升高,肌酸酐术后1 d和3 d均增加(P<0.05)。两组患者ALT及T组患者BUN和肌酸酐手术前后无显著变化(P﹥0.05)。结论低剂量七氟烷吸入麻醉和丙泊酚静脉麻醉对老年患者肝肾功能的影响无显著差异。Objective To investigate the influence of different anesthesia method on hepatic and renal function in elder patients under gastrointestinal surgery. Methods Fifty-five patients were randomly divided into propofol anesthesia groups and sevoflurane anesthesia groups. The hepatic and renal function, aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, blood urea nitrogen （BUN） and creatinine were tested at preoperation （baseline）, postoperative 1 day and 3 days. Results AST was increased at postoperative 1 day and 3 days,compared with that of the preop- eration in the Group S and Group T.Serum BUN at 3 day and ereatinine at 1 day and 3 days were significantly higher from the preoperative values in Group S（P〈0.05）,but the values were within its normal limit.ALT was not changed af- ter anesthesia in the both groups.And Serum BUN and creatinine were not changed after anesthesia in the T groups（P 〉 0.05）.There were no significant differences in the ALT,AST,BUN and ereatinine between the groups （P 〉 0.05）. Con- clusion These results show that the changes of hepatic and renal effect after inhalation anesthesia with sevoflurane and remifentanil and TIVA with propofol and remifentanil for gastrointestinal surgery were clinically insignficant,and there was no difference between the two methods.

关 键 词：吸入麻醉 全凭静脉麻醉 老年患者 肝肾功能 

分 类 号：R614[医药卫生—麻醉学]